SKU: 45942308519

PCSK9 Recombinant Rabbit mAb (SDT-424-252)

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Description

PCSK9 Recombinant Rabbit mAb (SDT-424-252)Product Specification Host Rabbit Synonyms Neural apoptosis regulated convertase 1 (NARC 1); Proprotein convertase 9 (PC9); Subtilisin kexin like protease PC9 Immunogen Recombinant Protein Accession Q8NBP7 Clone Number SDT 424 252 Antibody Type Recombinant mAb Isotype IgG Application Sandwich ELISA Reactivity Hu Cross Reactivity Does not recognize CHI3L1 Purification Protein A Concentration 2 mg ml Purity >95% by HPLC Conjugation Unconjugated Physical

Product Specification


Host Rabbit
Synonyms Neural apoptosis-regulated convertase 1 (NARC-1); Proprotein convertase 9 (PC9); Subtilisin/kexin-like protease PC9
Immunogen Recombinant Protein
Accession Q8NBP7
Clone Number SDT-424-252
Antibody Type Recombinant mAb
Isotype IgG
Application Sandwich ELISA
Reactivity Hu
Cross Reactivity Does not recognize CHI3L1
Purification Protein A
Concentration 2 mg/ml
Purity >95% by HPLC
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

Na-citrate, pH 6.0, 0.03% Proclin 300

Stability & Storage

12 months from date of receipt, 2 to 8 °C as supplied

Dilution


application dilution species
Sandwich ELISA N/A

Background

PCSK9 is ubiquitously expressed in many tissues and cell types. PCSK9 binds to and degrades the receptor for low-density lipoprotein particles (LDL), which typically transport 3,000 to 6,000 fat molecules (including cholesterol) per particle, within extracellular fluid. The LDL receptor (LDLR), on liver and other cell membranes, binds and initiates ingestion of LDL-particles from extracellular fluid into cells and targets the complex to lysosomes for destruction. If PCSK9 is blocked, the LDL-LDLR complex separates during trafficking, with the LDL digested in the lysosome, but the LDLRs instead recycled back to the cell surface and so able to remove additional LDL-particles from the extracellular fluid. Therefore, blocking PCSK9 can lower blood LDL-particle concentrations. PCSK9 has medical importance because it acts in lipoprotein homeostasis. Agents that block PCSK9 can lower LDL particle concentrations. The first two PCSK9 inhibitors, alirocumab and evolocumab, were approved as once every two week injections, by the U.S. Food and Drug Administration in 2015 for lowering LDL-particle concentrations when statins and other drugs were not sufficiently effective or poorly tolerated. PCSK9 inhibitors are promising therapeutics for the treatment of people who exhibit statin intolerance, or as a way to bypass frequent dosage of statins for higher LDL concentration reduction. So, measurement of plasma PCSK9 level will be more useful for monitoring treatment effect.

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SKU: 45942308519

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4.5 ★★★★★
Based on 23 reviews
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Verified Purchase
nicole
Alexandria, US
★★★★★ 5
Excellent customer service and quality
Size: Super King, Size: Super King
Update: since my original review the company has reached out to me and apologized for the quality of the comforter i received. They replaced the comforter with a brand new one and didn't make me send back the old one either! This new one is great quality so i am very pleased. The comforter is super comfy and not too hot or too cold. It has some weight to it which i love because it makes it so much more cozy without making me too hot. I got the super king size and I love how big it is. My husband and i don't fight over the covers anymore. With this new comforter and the way they handled things i give this company and product 5 stars and would highly recommend this to anyone! Well, I just opened this comforter and already im finding issues. There are strings coming out and at least 2 stains I've found so far. Not sure if I should return this or what as I'm sure it would be really hard to fit this back into the case. Wish this was a better experience. This was very expensive too, so very disappointing.
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Reviewed in the United States on May 20, 2026
D
Verified Purchase
Drew
Lexington, US
★★★★★ 5
Love this comforter.
Size: Queen
Super comfortable and light and well worth the price. Excellent quality that I didn't think I'd find again. And without the dreaded returns of trying something and it not right. It feels like the same one I bought in 2007 at BB&B on Christmas Day for half off and that was $250. So normally a $500 comforter and as a matter of fact I still have it although the feathers are kind of falling out. I'll probably just need to take it to a seamstress and have her resell a few things but I'm still keeping that as I am going to keep this. Incredible feel and very warm for an L2. The design is great. I haven't washed it yet but on order to fluff it I basically put it in the dryer for an hour on delicates with no heat. It did come sealed in a small box but it was absolutely perfect after an hour on fluff with no heat. I will end up buying another one when I get a king size bed. All I need now is a duvet that feels just like this comforter. There was no scent as some people mentioned. It smelled fresh right out of the box.
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Reviewed in the United States on March 20, 2025
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Verified Purchase
Kalisha
Alexandria, US
★★★★★ 5
Update: replacement comforter is much better… really impressed with this small business
Size: Palatial King
Update: The comforter on my bed is now everything I hoped for: fluffy, warm, and wonderfully cozy. Getting here was a two-part story, and it’s the happy ending and the fantastic service that created it that I really want to share. I’ll be honest, my first comforter was a letdown. It arrived flat and thin and just never really… fluffed into the cozy cloud I was hoping for. I was pretty frustrated, which is why I left my original review. But then, something really nice happened. The company actually reached out to me directly. They were so kind, listened without getting defensive, and genuinely wanted to make it right. They sent a replacement, no questions asked, and the difference has been night and day. This new one is exactly what I’d imagined. It has a real, fluffy loft, it’s softer, and after letting it settle, it’s become the full, warm, and comfortable comforter I wanted from the start. My quick takeaways: · A small business that stands behind their work. This meant a lot. · Customer service was top-notch kind, FAST, and professional. · The replacement is clearly better quality: fuller, softer, and warmer. · It’s a completely different (and better) experience than the first. I really value when a company just focuses on fixing things. The way they handled this completely changed my perspective. While the first one missed the mark, their response and the quality of the replacement have made me a happy customer. I’m glad I gave them the chance to make it right, and I’m finally cozy under the comforter I was hoping for.
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Reviewed in the United States on January 10, 2026
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Verified Purchase
Clyde D Triplett
Grantham, US
★★★★★ 5
Very Nice Comforter
Size: King
So far, very happy with my purchase, (King size comforter). Just received yesterday, unpackaged and put inside my duvet, then realized the instructions recommend you place it in the dryer, (as it comes vacuum packed). I really didn’t feel like messing with the duvet again and yet the comforter still fluffed out very nice. The outer shell is very soft, it has decorative piping around the edges and the filling is evenly spread out throughout all the pockets. One of the nicest features are the tabs, located on all four corners and in the middle of each side, (to tie to the inside of your duvet, if your duvet has the little inner strings) great for keeping the comforter in place.
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Reviewed in the United States on May 24, 2026
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Verified Purchase
Emily K. O'Neill
Draper, US
★★★★★ 4
Just one con…
Size: Palatial King
Loved everything about this duvet: great quality, true-to-size, 8 ties and REALLY big & fluffy. It was just way too warm for us, even during the winter. Wish we could find a duvet this full that was cooler.
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Reviewed in the United States on April 6, 2026

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