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Description
Inhibin alpha Recombinant Rabbit mAb (SDT-3212-24)Product Specification Host Rabbit Antigen Inhibin alpha Synonyms Inhibin alpha chain; INHA Immunogen Synthetic Peptide Location Secreted Accession P05111 Clone Number SDT 3212 24 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, IF Reactivity Hu, Ms, Rt Positive Sample mouse testis, mouse ovary, rat testis Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40%
Product Specification
| Host | Rabbit |
| Antigen | Inhibin alpha |
| Synonyms | Inhibin alpha chain; INHA |
| Immunogen | Synthetic Peptide |
| Location | Secreted |
| Accession | P05111 |
| Clone Number | SDT-3212-24 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, IF |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | mouse testis, mouse ovary, rat testis |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:10000 | Ms, Rt |
| IHC-P | 1:1000 | Hu, Ms, Rt |
| IF | 1:100 | Hu |
Background
Inhibin alpha is a 366-residue glycoprotein that dimerizes to form the common α-subunit of the inhibin family; it is synthesized primarily in Sertoli cells of the testis and granulosa cells of the ovary, where it partners with either a βA or βB chain to create inhibin A or inhibin B, both of which act as potent negative-feedback regulators of pituitary FSH secretion by antagonizing activin signaling through competition for the type II activin receptor, thereby governing gametogenesis and steroidogenesis; beyond reproduction, inhibin alpha is a sensitive serum tumor marker for granulosa-cell and Sertoli-cell neoplasms, and its expression is controlled by gonadotropins, local growth factors, and epigenetic mechanisms, making it a key node in the hypothalamic–pituitary–gonadal axis.
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