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Description
Biotin Mouse Anti-Human CD42b Antibody (S-935-7)Product Specification Host Mouse Antigen CD42b Synonyms Platelet glycoprotein Ib alpha chain; GP Ib alpha; GPIb alpha; GPIbA; Glycoprotein Ibalpha; Antigen CD42b alpha; GP1BA Immunogen Recombinant Protein Location Membrane Accession P07359 Clone Number S 935 7 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample Fresh human peripheral blood cells Purification Protein G Concentration 0. 2 mg ml Conjugation Biotin
Product Specification
| Host | Mouse |
| Antigen | CD42b |
| Synonyms | Platelet glycoprotein Ib alpha chain; GP-Ib alpha; GPIb-alpha; GPIbA; Glycoprotein Ibalpha; Antigen CD42b-alpha; GP1BA |
| Immunogen | Recombinant Protein |
| Location | Membrane |
| Accession | P07359 |
| Clone Number | S-935-7 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Fresh human peripheral blood cells |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Biotin |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 30 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD42b, also known as glycoprotein Ib alpha (GPIbα), is a type I transmembrane glycoprotein expressed on platelets and megakaryocytes. It is a key component of the GPIb-IX-V receptor complex, which plays a critical role in platelet adhesion and thrombus formation by binding to von Willebrand factor (vWF) at sites of vascular injury. CD42b interacts with various molecules, including thrombin, coagulation factors XI and XII, and P-selectin, contributing to hemostasis and thrombosis. Mutations or polymorphisms in CD42b are associated with diseases such as Bernard-Soulier syndrome and platelet-type von Willebrand disease.
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Exchange/Return Notes
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