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Description
Prolactin R/PRLR Fc Chimera Protein, HumanProduct Specification Species Human Synonyms Prolactin receptor, PRL R Accession P16471 Amino Acid Sequence Gln25 Asp234 with hIgG1 Fc Tag at the C Terminus Expression System HEK293 Molecular Weight 55 70kDa (Reducing) Purity 90% by SDS PAGE,> 80% by HPLC Conjugation Unconjugated Tag Human IgG1 Fc Physical Appearance Lyophilized powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in
Product Specification
| Species | Human |
| Synonyms | Prolactin receptor, PRL-R |
| Accession | P16471 |
| Amino Acid Sequence | Gln25-Asp234 with hIgG1 Fc Tag at the C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 55-70kDa (Reducing) |
| Purity | ＞90% by SDS-PAGE,> 80% by HPLC |
| Conjugation | Unconjugated |
| Tag | Human IgG1 Fc |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1.Harris J, Stanford PM, Oakes SR, Ormandy CJ. Prolactin and the prolactin receptor: new targets of an old hormone. Ann Med. 2004;36(6):414-25. |
Background
Prolactin receptor (PRLR) is a member of the cytokine receptor superfamily, composed of an extracellular ligand-binding domain, a single transmembrane domain, and an intracellular signaling domain, with three isoforms (long, short, and intermediate). Upon binding to prolactin, it activates the JAK2-STAT5 signaling pathway to regulate physiological processes including mammary gland development, lactation, metabolism, and immune modulation. Clinical studies have demonstrated that PRLR is highly expressed in various tumors such as breast and prostate cancers, promoting cancer cell proliferation, invasion, and drug resistance through autocrine/paracrine loops, making it an emerging therapeutic target for antitumor treatment, with monoclonal antibodies and small molecule antagonists currently under clinical development.
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