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Description
IL-27 Ra/WSX-1/TCCR Fc Chimera Protein, HumanProduct Specification Species Human Synonyms IL27RA,CRL1,WSX1,TCCR,IL 27R alpha,ZcytoR1 Accession Q6UWB1 Amino Acid Sequence Gly34 Lys516 with Fc at the C Terminus Expression System HEK293 Molecular Weight 100 120kDa (Reducing) Purity 95% by SDS PAGE & > 90% SEC HPLC Conjugation Unconjugated Tag Human IgG1 Fc Physical Appearance Lyophilized Powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according to the
Product Specification
| Species | Human |
| Synonyms | IL27RA,CRL1,WSX1,TCCR,IL-27R-alpha,ZcytoR1 |
| Accession | Q6UWB1 |
| Amino Acid Sequence | Gly34-Lys516 with Fc at the C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 100-120kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE & > 90% SEC-HPLC |
| Conjugation | Unconjugated |
| Tag | Human IgG1 Fc |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1.Poole JA, Schwab A, Thiele GM, England BR, Nelson AJ, Gleason A, Duryee MJ, Bailey KL, Romberger DJ, Hershberger D, Van De Graaff J, May SM, Walenz R, Kramer B, Mikuls TR. Unique transcriptomic profile of peripheral blood monocytes in rheumatoid arthritis-associated interstitial lung disease. Rheumatology (Oxford). |
Background
The interleukin-27 receptor subunit alpha (IL27RA), also known as WSX-1 or TCCR, is a member of the type I cytokine receptor family that forms the interleukin-27 receptor heterodimer together with glycoprotein 130 (IL6ST/gp130). Structurally characterized by three fibronectin type-III domains, IL27RA is highly expressed in lymphoid tissues including spleen, lymph nodes, and peripheral blood leukocytes, with particularly strong expression in resting/naive CD4+ and CD8+ T cells.Functioning as the specific ligand-binding component for interleukin-27, IL27RA requires association with gp130 for effective signal transduction through STAT1 and STAT3 pathways. This receptor system plays crucial roles in both adaptive and innate immunity. In adaptive immunity, it promotes Th1-type immune responses by initiating Th1 cell differentiation through STAT1 activation and T-bet expression induction, while also stimulating proliferation of naive CD4+ T cells. In innate immunity, IL27RA contributes to innate defense mechanisms through direct actions on cells of the innate immune system. The receptor shares structural and sequential homology with the IL-12 receptor β2 chain, placing it within the IL-6/IL-12 cytokine family, and serves as a key regulator in bridging innate and adaptive immune responses.
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