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Description
Caspase-7 Recombinant Rabbit mAb (S-R254)Product Specification Host Rabbit Antigen Caspase 7 Synonyms CASP 7, Apoptotic protease Mch 3, CMH 1, ICE like apoptotic protease 3 Location Cytoplasm, Nucleus Accession P55210 Clone Number S R254 Antibody Type Recombinant mAb Application WB, IHC P, ICC, ICFCM Reactivity Hu Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05%BSA, 0. 03% Proclin 300 Stability &
Product Specification
| Host | Rabbit |
| Antigen | Caspase-7 |
| Synonyms | CASP-7, Apoptotic protease Mch-3, CMH-1, ICE-like apoptotic protease 3 |
| Location | Cytoplasm, Nucleus |
| Accession | P55210 |
| Clone Number | S-R254 |
| Antibody Type | Recombinant mAb |
| Application | WB, IHC-P, ICC, ICFCM |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | null |
| IHC | 1:2000 | null |
| ICC | 1:100 | null |
| ICFCM | 1:500 | null |
Background
Caspase-7 is a member of the caspase (cysteine aspartate protease) family of proteins, and has been shown to be an executioner protein of apoptosis. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing by upstream caspases (caspase-8, -9) at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme in the form of a heterotetramer. The precursor of this caspase is cleaved by caspase 3, caspase 10, and caspase 9. It is activated upon cell death stimuli and induces apoptosis.
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