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Description
TMEM219 Fc Chimera Protein, HumanProduct Specification Species Human Antigen TMEM219 Synonyms IGFBP 3R, Transmembrane protein 219, TMEM219 Accession Q86XT9 1 Amino Acid Sequence Ser39 Arg204, with C terminal Human IgG1 Fc Expression System HEK293 Molecular Weight 60 65kDa Purity 95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag Human Fc Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in
Product Specification
| Species | Human |
| Antigen | TMEM219 |
| Synonyms | IGFBP-3R, Transmembrane protein 219, TMEM219 |
| Accession | Q86XT9-1 |
| Amino Acid Sequence | Ser39-Arg204, with C-terminal Human IgG1 Fc |
| Expression System | HEK293 |
| Molecular Weight | 60-65kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | Human Fc |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1. Chang-Min Lee , Chuan Hua He.IL-13Rα2 uses TMEM219 in chitinase 3-like-1- induced signalling and effector responses.Nat Commun. 2016 Sep 15;7:12752. |
Background
TMEM219 is a recently discovered death receptor, which induces cell apoptosis by a Caspase-8-dependent mechanism, through the binding with its ligand, the Insulin-like growth factors binding protein 3 (IGFBP3). TMEM219 consists of four exons comprising the 915-base pair cDNA sequence on chromosome 16q13 and represents a 240-amino acid polypeptide. TMEM219 is expressed on pancreatic beta cells and that signaling through its ligand insulin-like growth factor binding protein 3 (IGFBP3) leads to beta cell loss and dysfunction. TMEM219 is an IL-13Rα2 binding partner that plays a critical role in many Chi3l1-induced, IL-13Rα2-mediated cellular and organ responses.
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