SKU: 4930200304

Alexa Fluor® 488 Rat Anti-Mouse PD-1 (CD279) Antibody (S-R496)

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Description

Alexa Fluor® 488 Rat Anti-Mouse PD-1 (CD279) Antibody (S-R496)Product Specification Host Rat Antigen PD 1 (CD279) Synonyms Programmed cell death protein 1; Protein PD 1; mPD 1; Pdcd1 Location Cell membrane Accession Q02242 Clone Number S R496 Antibody Type Rat mAb Isotype IgG2a Application FCM Reactivity Ms Purification Protein G Conjugation Alexa Fluor 488 Physical Appearance Liquid Storage Buffer PBS, 25% Glycerol, 1% BSA, 0. 3% Proclin 300 Stability & Storage 12 months from date of receipt reconstitution, 2

Product Specification


Host Rat
Antigen PD-1 (CD279)
Synonyms Programmed cell death protein 1; Protein PD-1; mPD-1; Pdcd1
Location Cell membrane
Accession Q02242
Clone Number S-R496
Antibody Type Rat mAb
Isotype IgG2a
Application FCM
Reactivity Ms
Purification Protein G
Conjugation Alexa Fluor® 488
Physical Appearance Liquid
Storage Buffer

PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300

Stability & Storage 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 5 μl per million cells in 100μl volume

Background

Programmed cell death protein 1 (PD-1), also known as CD279, is a type I transmembrane protein and a member of the CD28 immunoglobulin superfamily, encoded by the _PDCD1_ gene. It is primarily expressed on the surface of various immune cells, including T cells, B cells, macrophages, dendritic cells, and natural killer cells. PD-1 plays a crucial role in regulating immune responses by binding to its ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC), which are expressed on antigen-presenting cells and tumor cells. When PD-1 interacts with its ligands, it triggers inhibitory signals that downregulate T cell activity, preventing excessive immune responses and promoting self-tolerance. However, this pathway can also be exploited by cancer cells to evade immune surveillance, leading to tumor progression. As a result, PD-1 has become a key target in cancer immunotherapy, with several anti-PD-1 antibodies approved for treating various cancers, achieving significant and durable efficacy in some patients.

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SKU: 4930200304

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4.3 ★★★★★
Based on 27 reviews
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Mark H.
Dallas, US
★★★★★ 5
Very nice shirts but unusually long sleeves
Size: Large, Color: Light Green
PJ PAUL JONES Mens Dress Shirts Wrinkle Free Stretch Button Down Shirt. I bought white, coffee, grey, autumn green and apricot. Colors are true to the ads. I'm 6' , 170 lbs. I bought these in Large. They fit very well in shoulders, chest, and my big belly. As many reviews have stated, the sleeves are unusually long - coming down past my palms to my fingers. I would give them a 4 rating for that but I bought them with the intention of making them short sleeve. The white shirt is just too nice to change so I'll reserve that for weddings and funerals. The apricot is very nice but I just wouldn't wear that color as a casual shirt but it does go with my brown blaser so I'll keep it for rare occasions. I washed them in warm and put them thru warm dryer and didn't notice any shrinkage which I wouldn't expect with polyester. Very good shirts at very good price.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 30, 2026
T
Verified Purchase
Tamondo
Belleville, US
★★★★★ 5
A Solid Buy
Size: XX-Large, Color: Black
Purchased this shirt to wear to a concert. I love the material because it's stretchy and flexible unlike the traditional cotton. It's mainly wrinkle free but I ran a warm iron to get out the creases from being folded. I wore this with gray pants and it made my outfit feel put together. The sleeves are very easy to roll up and won't come undone. A very nice shirt to add to your clothing collection.
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Reviewed in the United States on April 10, 2026
J
Verified Purchase
J. Samson
Birmingham, US
★★★★★ 4
Good looking shirt that runs a bit big in sizing.
Size: X-Large, Color: Green Gray
Nice looking shirt for dress up or casual wearing. Feels like silk, pretty wrinkle free. Lots of colors to chose from at a good price. Runs a bit big in size. I found the sleeves very long for me. But I like the casual look, feel and coolness in the heat of summer for a long sleeve shirt.
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Reviewed in the United States on August 9, 2025
G
Verified Purchase
Guy
Boise, US
★★★★★ 5
Good shirt
Size: X-Large, Color: Sky Blue
Good fitting shirt. Looked good just like image shows
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Reviewed in the United States on April 27, 2026
G
Verified Purchase
Gloria Gina
Whiting, US
★★★★★ 5
I wear a medium and it fit perfect in all areas
Size: Medium, Color: Coffee
Best shirt for fit, comfort, style and price
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Reviewed in the United States on March 27, 2026

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