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Description
Myosin-11/SMMHC Recombinant Rabbit mAb (SDT-188-112)Product Specification Host Rabbit Antigen Myosin 11 SMMHC Synonyms smooth muscle myosin heavy chain, HSM V, SMMS 1, SM MYOSIN H, Myosin heavy chain 11, MYH11 Immunogen Synthetic Peptide Location Melanosome Accession P35749 Clone Number SDT 188 112 Antibody Type Recombinant mAb Application WB, IHC P, IF Reactivity Hu, Ms, Rt Predicted Reactivity Rb Purification Protein A Concentration 0. 25 mg ml Physical Appearance Liquid Storage Buffer PBS, 40%
Product Specification
| Host | Rabbit |
| Antigen | Myosin-11/SMMHC |
| Synonyms | smooth muscle myosin heavy chain, HSM-V, SMMS-1, SM-MYOSIN-H, Myosin heavy chain 11, MYH11 |
| Immunogen | Synthetic Peptide |
| Location | Melanosome |
| Accession | P35749 |
| Clone Number | SDT-188-112 |
| Antibody Type | Recombinant mAb |
| Application | WB, IHC-P, IF |
| Reactivity | Hu, Ms, Rt |
| Predicted Reactivity | Rb |
| Purification | Protein A |
| Concentration | 0.25 mg/ml |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:25000 | |
| IHC-P | 1:1000 | |
| IF | 1:125 |
Background
SMMHC is a structural component of the smooth muscle myosin molecule and is a specific marker of “terminal” smooth muscle differentiation [PMID: 10721417, PMID: 3882826]. SMMHC is composed of at least two isoforms: SM1 (204 kDa) and SM2 (200 kDa), both of which are encoded by a single gene [PMID: 9702855, PMID: 10998642]. The SM1 isoform is expressed in the MEC of normal mammary glands, fibrocystic diseases, and in myoepithelial derived tumours of the breast [PMID: 11493962, PMID: 9702855]. Furthermore, studies have documented that antibodies to SMMHC and calponin, both markers of terminal smooth muscle differentiation, are more specific for breast MEC than are other more commonly used antibodies, such as those that recognise SMA [PMID: 11493962].
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