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Description
S-RMab® BCL-6 Recombinant Rabbit mAb (SDT-103-21)Product Specification Host Rabbit Antigen BCL 6 Synonyms BCL5, LAZ3, ZBTB27, ZNF51,BCL6 Immunogen Synthetic Peptide Location Nucleus Accession P41182 Clone Number SDT 103 21 Antibody Type Rabbit mAb Application WB, IHC P, ICC, ICFCM Reactivity Hu Purification Protein A Concentration 0. 5 mg ml Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05%BSA, 0. 03% Proclin 300 Stability & Storage 12 months from date of receipt reconstitution, 20
Product Specification
| Host | Rabbit |
| Antigen | BCL-6 |
| Synonyms | BCL5, LAZ3, ZBTB27, ZNF51,BCL6 |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | P41182 |
| Clone Number | SDT-103-21 |
| Antibody Type | Rabbit mAb |
| Application | WB, IHC-P, ICC, ICFCM |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | |
| ICFCM | 1:500 | |
| ICC | 1:500 | |
| IHC-P | 1:500-1:1000 |
Background
B-cell lymphoma 6 (BCL6) is a protooncogene in adult and pediatric cancers, first identified in diffuse large B-cell lymphoma (DLBCL) where it acts as a repressor of the tumor suppressor TP53, conferring survival, protection, and maintenance of lymphoma cells. BCL6 expression in normal B cells is fundamental in the regulation of humoral immunity, via initiation and maintenance of the germinal centers (GC). Its role in B cells during the production of high affinity immunoglobins (that recognize and bind specific antigens) is believed to underpin its function as an oncogene. BCL6 is known to drive the self-renewal capacity of leukemia-initiating cells (LIC), with high BCL6 expression in acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), and glioblastoma (GBM) associated with disease progression and treatment resistance.
Shipping Notes
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Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
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