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Description
Human CCL26/Eotaxin-3 OneStep ELISA Kit (broad range)Product Specification Antigen CCL26 Eotaxin 3 Immunogen Recombinant Protein Antibody Type Recombinant mAb Reactivity Hu Purification Protein A Stability & Storage 12 months from date of receipt reconstitution, 2 to 8'C as supplied. Kit Precision Intra assay: 3. 1% Inter assay: 4. 2% Sample type Cell culture supernatant; Serum; Plasma EDTA, Plasma Citrate Assay type Sandwich (quantitative) Sensitivity 1. 940 pg mL Range 12. 29 pg mL 3000 pg mL Recovery
Product Specification
| Antigen | CCL26/Eotaxin-3 |
| Immunogen | Recombinant Protein |
| Antibody Type | Recombinant mAb |
| Reactivity | Hu |
| Purification | Protein A |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8'C as supplied. |
Kit
| Precision | Intra-assay: 3.1%； Inter-assay: 4.2% |
| Sample type | Cell culture supernatant; Serum; Plasma-EDTA, Plasma-Citrate |
| Assay type | Sandwich (quantitative) |
| Sensitivity | 1.940 pg/mL |
| Range | 12.29 pg/mL – 3000 pg/mL |
| Recovery | Cell culture supernatant: 97% Serum: 92% Plasma-EDTA: 115% Plasma-Citrate: 119% |
| Assay time | 70 minutes |
| Species reactivity | Hu |
Background
Human CCL26, also known as Eotaxin-3, is a small cytokine belonging to the CC chemokine family, primarily involved in allergic inflammation and eosinophil recruitment. Encoded by the CCL26 gene located on chromosome 7q11.23, this protein is secreted by endothelial cells, epithelial cells, and fibroblasts, particularly in response to stimulation by IL-4 and IL-13. Its primary function is to bind specifically to the chemokine receptor CCR3, which is highly expressed on eosinophils, basophils, and Th2 lymphocytes, thereby mediating their chemotaxis to sites of allergic inflammation. Unlike its homolog Eotaxin-1 (CCL11), CCL26 is selectively induced by Th2-associated cytokines and plays a prominent role in chronic allergic conditions such as atopic dermatitis, asthma, and eosinophilic esophagitis. Elevated expression of CCL26 has been observed in diseased tissues and correlates with eosinophil infiltration and disease severity. Due to its specific role in mediating type 2 inflammatory responses, CCL26 is considered both a diagnostic biomarker and a potential therapeutic target for allergic disorders.
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