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Description
TAK1 Recombinant Rabbit mAb (S-2482-39)Product Specification Host Rabbit Antigen TAK1 Synonyms Mitogen activated protein kinase kinase kinase 7; Transforming growth factor beta activated kinase 1 (TGF beta activated kinase 1); MAP3K7 Immunogen Synthetic Peptide Location Cytoplasm, Cell membrane Accession O43318 Clone Number S 2482 39 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Ms, Rt, Mk Positive Sample HEK 293, HeLa, A431, A549, NIH 3T3, C6, COS 7 Purification
Product Specification
| Host | Rabbit |
| Antigen | TAK1 |
| Synonyms | Mitogen-activated protein kinase kinase kinase 7; Transforming growth factor-beta-activated kinase 1 (TGF-beta-activated kinase 1); MAP3K7 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Cell membrane |
| Accession | O43318 |
| Clone Number | S-2482-39 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms, Rt, Mk |
| Positive Sample | HEK-293, HeLa, A431, A549, NIH/3T3, C6, COS-7 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:5000 | Hu, Ms, Rt, Mk |
Background
TAK1 (MAP3K7) is a ubiquitously expressed serine/threonine kinase that acts as a central signaling hub by integrating cues from TGF-β, inflammatory cytokines (TNF-α, IL-1), pattern-recognition receptors (TLR, NOD-like receptors) and cellular stress to catalyze the activation of IKK and MAP2Ks (MKK3/6, MKK4/7), thereby driving the NF-κB, p38, JNK and ERK pathways that collectively regulate inflammation, innate and adaptive immunity, cell survival, differentiation and metabolic adaptation; its activity is tightly controlled through stimulus-inducible assembly with regulatory binding partners TAB1, TAB2 and TAB3 and by polyubiquitin scaffolds, and genetic or pharmacologic dysregulation of TAK1 is linked to inflammatory diseases, autoimmunity and cancer.
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