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Description
PTK7/CCK4 His Tag Protein, HumanProduct Specification Species Human Synonyms PTK7, CCK4, CCK 4, Tyrosine protein kinase like 7, Protein tyrosine kinase 7 Accession Q13308 Amino Acid Sequence Ala31 Thr704, with C terminal 10*His
Product Specification
| Species | Human |
| Synonyms | PTK7, CCK4, CCK-4, Tyrosine-protein kinase-like 7, Protein-tyrosine kinase 7 |
| Accession | Q13308 |
| Amino Acid Sequence | Ala31-Thr704, with C-terminal 10*His AIVFIKQPSSQDALQGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAGVRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQDSQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYRCMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKWERADGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTGGGSGGGSHHHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 95-110kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Lichtig H. et al. (2019) Ptk7 proteolytic fragment proteins function during early xenopus development. Dev Biol. 453(1): 48-55. 2、Damelin M. et al. (2017) A ptk7-targeted antibody-drug conjugate reduces tumor-initiating cells and induces sustained tumor regressions. Sci Transl Med 9 (372): eaag2611. |
Background
Protein tyrosine kinase 7 (PTK7), also known as colon carcinoma kinase 4 (CCK4), is a member of the receptor tyrosine kinase superfamily. PTK7 is a type I transmembrane receptor with a large extracellular domain (ECD) containing 7 Ig-like C2 type loops, a transmembrane domain, and a cytoplasmic tyrosine kinase homology domain. PTK7 has been shown to be an important regulator of the Wnt signaling pathways, both canonical and non-canonical, and is linked to the regulation of the planar cell polarity pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.
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4.4 ★★★★★
Based on 19 reviews
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Product Reviews
★★★★★ 5
Great!
It was great and soft! Very warm so maybe not a summertime blanket if it gets really warm by you! It’s really pretty and looks just like the pictures!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 6, 2026
★★★★★ 5
Beautiful!
Size: King (104"x90"), Color: Cheetah Print Brown
Soft, thick, and warm. Also beautiful.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 13, 2026
★★★★★ 3
Pretty not practical
Size: Queen (90"x90"), Color: Tiger Print Brown
I want to like this blanket because it’s soft and pretty but it’s unfortunately one of the most annoying blankets I’ve ever had. I got this blanket to replace my comforter for summer because it’s too hot and this blanket wouldn’t be. Well because or of it’s soft underneath and the fact that the two layers are only sewn together at the edges all night long it rolls into itself and won’t stay in place. I’ve tried tucking it under my mattress but by morning my bottom half is freezing while my top half sweats because the entire blanket will have slid up.
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Reviewed in the United States on May 15, 2026
★★★★★ 5
Comfortable and durable
Size: King (104"x90"), Color: Cheetah Print Brown
I love this comforter. It has survived many washes and 3 dogs sleeping in it every night with no issues. It looks great in my room and is very comfortable.
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Reviewed in the United States on May 13, 2026
★★★★★ 5
Noce product2
Size: Queen (90"x90"), Color: Tiger Print Brown
I use this regularly. It washes well. It is very warm and cozy.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 2, 2026
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