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Description
RIBEYE/CTBP2 Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen RIBEYE CTBP2 Synonyms C terminal binding protein 2 Immunogen Synthetic Peptide Location Nucleus, Synapse Accession P56545 Antibody Type Polyclonal antibody Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt Positive Sample HeLa, SK BR 3, SH SY5Y, MCF7, mouse brain, mouse stomach, rat brain, rat stomach Predicted Reactivity Bv Purification Immunogen Affinity Concentration 0. 5 mg ml Conjugation
Product Specification
| Host | Rabbit |
| Antigen | RIBEYE/CTBP2 |
| Synonyms | C-terminal-binding protein 2 |
| Immunogen | Synthetic Peptide |
| Location | Nucleus, Synapse |
| Accession | P56545 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HeLa, SK-BR-3, SH-SY5Y, MCF7, mouse brain, mouse stomach, rat brain, rat stomach |
| Predicted Reactivity | Bv |
| Purification | Immunogen Affinity |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| IHC-P | 1:1000 | Hu, Ms, Rt |
| ICC | 1:1000 | Hu |
Background
The RIBEYE protein is a core structural component of the synaptic ribbon in retinal bipolar cells and photoreceptor cells. It is one of two isoforms (the shorter B-domain-deficient variant) encoded by the CTBP2 gene through an alternative promoter. Functioning as a scaffold protein of the synaptic ribbon, RIBEYE interacts with other synaptic components (such as RIM and Piccolo) via its unique N-terminal A-domain, while its C-terminal D-domain—homologous to CTBP1/2—mediates dimerization and may participate in metabolic regulation. This protein plays a crucial role in synaptic vesicle tethering, organizing release sites, and coordinating calcium signaling. Mutations in RIBEYE are associated with retinal disorders and hearing impairments. Research on RIBEYE provides insights into the mechanisms of specialized synaptic transmission and the pathological basis of neuro-sensory diseases.
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