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Description
Cytokeratin 19 Recombinant Rabbit mAb (SDT-107-19)Product Specification Host Rabbit Antigen Cytokeratin 19 Synonyms KRT19, CK 19 Immunogen Synthetic Peptide Location Cell membrane Accession P08727 Clone Number SDT 107 19 Antibody Type Rabbit mAb Application WB, IHC P, ICC, FC Reactivity Hu, Ms, Rt Purification Protein A Concentration 0. 25mg ml Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05%BSA, 0. 03% Proclin 300 Stability & Storage 12 months from date of receipt reconstitution,
Product Specification
| Host | Rabbit |
| Antigen | Cytokeratin 19 |
| Synonyms | KRT19, CK-19 |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane |
| Accession | P08727 |
| Clone Number | SDT-107-19 |
| Antibody Type | Rabbit mAb |
| Application | WB, IHC-P, ICC, FC |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein A |
| Concentration | 0.25mg/ml |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:1000 | |
| FC | 1:500 | |
| WB | 1:500 | |
| ICC | 1:250 |
Background
Cytokeratin 19 is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Keratin 19 is a type I keratin. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically found in the periderm, the transiently superficial layer that envelops the developing epidermis. KRT19 is also known as Cyfra 21-1.Due to its high sensitivity, KRT19 is the most used marker for the RT-PCR-mediated detection of tumor cells disseminated in lymph nodes, peripheral blood, and bone marrow of breast cancer patients.
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