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Description
FUNDC1 Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen FUNDC1 Synonyms FUN14 domain containing protein 1 Immunogen Synthetic Peptide Location Mitochondrion Accession Q8IVP5 Antibody Type Polyclonal antibody Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt Positive Sample HeLa, T 47D, MCF7, RAW264. 7, mouse brain, C6, rat brain Purification Immunogen Affinity Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40%
Product Specification
| Host | Rabbit |
| Antigen | FUNDC1 |
| Synonyms | FUN14 domain-containing protein 1 |
| Immunogen | Synthetic Peptide |
| Location | Mitochondrion |
| Accession | Q8IVP5 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HeLa, T-47D, MCF7, RAW264.7, mouse brain, C6, rat brain |
| Purification | Immunogen Affinity |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:500-1:1000 | Hu, Ms, Rt |
| IHC-P | 1:500 | Hu, Ms, Rt |
Background
FUNDC1 (FUN14 domain containing 1) is a protein located in the outer mitochondrial membrane and mitochondrial-associated membranes (MAMs), playing a crucial role in regulating mitochondrial quality control through mitophagy, mitochondrial dynamics, and biogenesis. It contains an LC3 interaction region (LIR) motif that binds to LC3, facilitating the selective degradation of damaged mitochondria to maintain cellular health. Under hypoxic conditions, FUNDC1 is phosphorylated by ULK1 and dephosphorylated by PGAM5, enhancing its interaction with LC3 and promoting mitophagy. Additionally, FUNDC1 collaborates with OPA1 to modulate mitochondrial dynamics, and its phosphorylation state affects mitochondrial morphology and the balance between fusion and fission. It is extensively expressed in the heart and has been implicated in various diseases, including metabolic cardiomyopathy, cardiac remodeling, and myocardial ischemia-reperfusion injury.
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