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Description
4E-BP1 Recombinant Rabbit mAb (S-1654-47)Product Specification Host Rabbit Antigen 4E BP1 Synonyms Eukaryotic translation initiation factor 4E binding protein 1; 4E BP1; eIF4E binding protein 1; Phosphorylated heat and acid stable protein regulated by insulin 1 (PHAS I); EIF4EBP1 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus Accession Q13541 Clone Number S 1654 47 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu Positive Sample HeLa, MCF7, HepG2,
Product Specification
| Host | Rabbit |
| Antigen | 4E-BP1 |
| Synonyms | Eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1 (PHAS-I); EIF4EBP1 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus |
| Accession | Q13541 |
| Clone Number | S-1654-47 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu |
| Positive Sample | HeLa, MCF7, HepG2, SH-SY5Y, HEK-293, K562, human cervix cancer, human colon, human colon cancer, human prostate, human prostate cancer |
| Predicted Reactivity | / |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:1000 | Hu |
| ICC | 1:500 | Hu |
Background
4E-BP1 (eukaryotic initiation factor 4E-binding protein 1) is a key regulator of protein translation and plays a crucial role in controlling the assembly of the eIF4F complex, which is essential for cap-dependent translation initiation. It is the most widely expressed and well-characterized member of the 4E-BP family in mammalian cells. When active, 4E-BP1 binds to eIF4E, preventing its interaction with eIF4G and thereby inhibiting the formation of the eIF4F complex, which is necessary for the translation of many oncogenic mRNAs with structured 5′-UTRs. This mechanism is critical in suppressing tumor development, as hyperactive eIF4E-dependent translation contributes to the upregulation of pro-tumorigenic genes in cancer cells. The activity of 4E-BP1 is regulated by various signaling pathways, including the PI3K/AKT/mTOR pathway, which can lead to its phosphorylation and inactivation, allowing eIF4E to promote translation. Reactivating 4E-BP1 through mTOR inhibition or other mechanisms has been shown to have tumor-suppressive effects.
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