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Description
Endoglin/CD105 His Tag Protein, HumanProduct Specification Species Human Synonyms CD105 antigen; CD105; Endoglin; ENDOsler Rendu Weber syndrome 1; ENG; HHT1FLJ41744; ORW; ORW1 Accession P17813 1 Amino Acid Sequence Glu26 Gly586, with C terminal His Expression System HEK293 Molecular Weight 85 105kDa (Reducing) Purity 95% by SDS PAGE & SEC HPLC Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, PH7. 4, 5% trehalose
Product Specification
| Species | Human |
| Synonyms | CD105 antigen; CD105; Endoglin; ENDOsler-Rendu-Weber syndrome 1; ENG; HHT1FLJ41744; ORW; ORW1 |
| Accession | P17813-1 |
| Amino Acid Sequence | Glu26-Gly586, with C-terminal His |
| Expression System | HEK293 |
| Molecular Weight | 85-105kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE & SEC-HPLC |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.MINI REVIEW article Front. Med., 30 January 2019 Sec. Translational Medicine Volume 6 - 2019 . |
Background
Endoglin (ENG), endothelial glycoprotein, also known as CD105, is a coreceptor of the transforming growth factor-β (TGFβ) family signaling complex, which is highly expressed on endothelial cells and plays a key role in angiogenesis. Endoglin contains an RGD tripeptide which is a key recognition structure in cellular adhesion,,suggesting a critical role for endoglin in the binding of endothelial cells to integrins and/or other RGD receptors. As a TGF-beta coreceptor, CD105/Endoglin activates SMAD transcription factors, participating in the TGF-beta/BMP signaling cascade.
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