SKU: 53637486301

Alexa Fluor® 700 Armenian hamster Anti-Mouse CD80 Antibody (S-R520)

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Ships within 48 hours · Estimated delivery Aug 30 - Sep 4

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Description

Alexa Fluor® 700 Armenian hamster Anti-Mouse CD80 Antibody (S-R520)Product Specification Host Armenian hamster Antigen CD80 Synonyms T lymphocyte activation antigen CD80; Activation B7 1 antigen (B7); B7; Cd80 Location Cell membrane Accession Q00609 Clone Number S R520 Antibody Type Recombinant mAb Isotype IgG Application FCM Reactivity Ms Positive Sample LPS treated C57BL 6 mouse splenocytes Purification Protein G Concentration 0. 2 mg ml Conjugation Alexa Fluor 700 Physical Appearance Liquid Storage Buffer PBS, 1%

Product Specification


Host Armenian hamster
Antigen CD80
Synonyms T-lymphocyte activation antigen CD80; Activation B7-1 antigen (B7); B7; Cd80
Location Cell membrane
Accession Q00609
Clone Number S-R520
Antibody Type Recombinant mAb
Isotype IgG
Application FCM
Reactivity Ms
Positive Sample LPS treated C57BL/6 mouse splenocytes
Purification Protein G
Concentration 0.2 mg/ml
Conjugation Alexa Fluor® 700
Physical Appearance Liquid
Storage Buffer

PBS, 1% BSA, 0.3% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 1.25μl per million cells in 100μl volume Ms

Background

CD80,also known as B7-1,is a co - stimulatory molecule expressed on antigen - presenting cells (APCs) such as dendritic cells,macrophages and B cells. It plays a crucial role in the immune response by interacting with CD28 on T cells to provide a co - stimulatory signal necessary for T cell activation,thereby promoting T cell proliferation and differentiation. Additionally,CD80 can also bind to CTLA - 4,an inhibitory receptor on T cells,which acts as a negative regulator of T cell activation. This binding can inhibit the immune response and maintain immune tolerance. Moreover,CD80 - CD28 interaction is involved in the regulation of various immune - related processes,including the formation of immunological synapses and the regulation of cytokine production.

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Exchange/Return Notes
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SKU: 53637486301

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