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Description
Rat Anti-Mouse CD22 Antibody (S-R669)Product Specification Host Rat Antigen CD22 Synonyms B cell receptor CD22; B lymphocyte cell adhesion molecule (BL CAM); Sialic acid binding Ig like lectin 2 (Siglec 2); T cell surface antigen Leu 14; Lyb 8; Siglec2 Location Cell membrane Accession P35329 Clone Number S R669 Antibody Type Rat mAb Isotype IgG1,k Application FCM Reactivity Ms Positive Sample C57BL 6 mouse splenocytes Purification Protein G Concentration 2 mg ml Conjugation Unconjugated
Product Specification
| Host | Rat |
| Antigen | CD22 |
| Synonyms | B-cell receptor CD22; B-lymphocyte cell adhesion molecule (BL-CAM); Sialic acid-binding Ig-like lectin 2 (Siglec-2); T-cell surface antigen Leu-14; Lyb-8; Siglec2 |
| Location | Cell membrane |
| Accession | P35329 |
| Clone Number | S-R669 |
| Antibody Type | Rat mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse splenocytes |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 1:2000 | Ms |
Background
CD22, also known as cluster of differentiation 22, is a 140 kDa type I transmembrane glycoprotein and a member of the Siglec (sialic acid-binding immunoglobulin-like lectin) family. It is predominantly expressed on the surface of mature B cells and to a lesser extent on some immature B cells. The extracellular domain of CD22 consists of seven immunoglobulin-like domains, while its cytoplasmic tail contains conserved tyrosine motifs, including immunoreceptor tyrosine-based inhibitory motifs (ITIMs), which play a crucial role in inhibiting B cell receptor (BCR) signaling. CD22 functions as a negative regulator of B cell activation, helping to prevent overactivation of the immune system and the development of autoimmune diseases. Additionally, it is involved in B cell trafficking and maintaining peripheral B cell tolerance. CD22's interaction with sialic acid-containing molecules on various cell types allows it to modulate B cell responses and maintain immune homeostasis.
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