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Description
Calponin-1 Recombinant Rabbit mAb(SDT-080-78)Product Specification Host Rabbit Antigen Calponin 1 Synonyms Basic calponin, Calponin H1 (smooth muscle), CNN1CALP Immunogen Synthetic Peptide Accession P51911 Clone Number SDT 080 78 Antibody Type Rabbit mAb Application WB, IHC P, ICC, IF Reactivity Hu, Ms, Rt Purification Protein A Concentration 0. 5mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05%BSA, 0. 03% Proclin 300 Stability & Storage 12 months
Product Specification
| Host | Rabbit |
| Antigen | Calponin-1 |
| Synonyms | Basic calponin, Calponin H1 (smooth muscle), CNN1，CALP |
| Immunogen | Synthetic Peptide |
| Accession | P51911 |
| Clone Number | SDT-080-78 |
| Antibody Type | Rabbit mAb |
| Application | WB, IHC-P, ICC, IF |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein A |
| Concentration | 0.5mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:2000 | |
| ICC | 1:250 | |
| WB | 1:1000 | |
| IF | 1:1000 |
Background
Calponin-1 is a 34 kDa actin-binding protein with regions of sequence homology to cardiac troponin I and T. It is located in the cytoskeleton and contractile apparatus of differentiated smooth muscle cells. There are 3 isoforms of calponin: calponin-1 (h1 or basic), calponin-2 (h2 or neutral), and calponin-3 (h3 or acidic). Calponin-1 is implicated in the regulation of smooth muscle contraction by mediating intracellular signaling responses to some vasoconstrictors by acting as a contractile scaffold protein. This mechanism is based on results in aortic smooth muscle cells stimulated with phenylephrine, which showed calponin-1 connecting protein kinase C and ERK1/2 pathways to promote contractility.
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