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Description
IL-17A Protein, MouseProduct Specification Species Mouse Synonyms IL 17A,Interleukin 17A,CTLA 8,IL 17, Accession Q62386 Amino Acid Sequence Ala26 Ala158 Expression System HEK293 Molecular Weight 12 22 kDa (Reducing) Purity >95% by SDS PAGE and HPLC. Endotoxin <0. 1EU g Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized powder Storage Buffer PBS, pH7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid
Product Specification
| Species | Mouse |
| Synonyms | IL-17A,Interleukin-17A,CTLA-8,IL-17, |
| Accession | Q62386 |
| Amino Acid Sequence | Ala26-Ala158 |
| Expression System | HEK293 |
| Molecular Weight | 12-22 kDa (Reducing) |
| Purity | >95% by SDS-PAGE and HPLC. |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Nat Immunol. 2005 Nov;6(11):1123-32. |
Background
Interleukin-17A (IL-17A), also referred to as cytotoxic T-lymphocyte-associated antigen 8 (CTLA8), is a key proinflammatory cytokine synthesized by activated T cells. It exerts its biological effects by regulating the activities of NF-kappaB and mitogen-activated protein kinases, which are critical in inflammatory signaling pathways. Additionally, IL-17A can induce the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), while also promoting the production of nitric oxide (NO), all of which contribute to amplifying inflammatory responses. This cytokine exists in two forms: glycosylated and nonglycosylated, each with potential differences in biological activity. Notably, elevated levels of IL-17A have been closely linked to the pathogenesis of various chronic inflammatory disorders. These include rheumatoid arthritis, where it drives joint inflammation, psoriasis, contributing to skin lesion formation, and multiple sclerosis, involved in neuroinflammation. Understanding the role of IL-17A in these conditions has become a focus of research for developing targeted therapeutic strategies.
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