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Description
YTHDF1 Recombinant Rabbit mAb (S-2443-28)Product Specification Host Rabbit Antigen YTHDF1 Synonyms YTH domain containing family protein 1; Dermatomyositis associated with cancer putative autoantigen 1 homolog (DACA 1 homolog); Ythdf1 Immunogen Synthetic Peptide Location Cytoplasm Accession P59326 Clone Number S 2443 28 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, IF Reactivity Hu, Ms, Rt Positive Sample NIH 3T3, PC 12, rat testis Purification Protein A Concentration 0. 5
Product Specification
| Host | Rabbit |
| Antigen | YTHDF1 |
| Synonyms | YTH domain-containing family protein 1; Dermatomyositis associated with cancer putative autoantigen 1 homolog (DACA-1 homolog); Ythdf1 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm |
| Accession | P59326 |
| Clone Number | S-2443-28 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, IF |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | NIH/3T3, PC-12, rat testis |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Ms, Rt |
| IHC-P | 1:250-1:1000 | Hu, Ms,Rt |
| IF | 1:500 | Ms |
Background
YTHDF1 (YTH N6-methyladenosine RNA binding protein F1) is a cytoplasmic reader of the m6A epitranscriptomic mark that selectively binds N6-methylated adenosines within mRNAs and, by recruiting eIF3 and other translation initiation factors, enhances the ribosome loading and protein synthesis of its target transcripts, thereby influencing cell proliferation, synaptic plasticity, immune responses and tumorigenesis; structurally it contains an N-terminal intrinsically disordered region and a C-terminal YTH domain that confers high-affinity m6A recognition, and its expression or phosphorylation state is frequently dysregulated in multiple cancers, making it an emerging therapeutic target for small-molecule or oligonucleotide-based interventions.
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