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Description
CCL2/MCP-1 Recombinant Rabbit mAb (SDT-1737-66)Product Specification Host Rabbit Antigen CCL2 MCP 1 Synonyms C C motif chemokine 2; HC11; Monocyte chemoattractant protein 1; Monocyte chemotactic and activating factor (MCAF); Monocyte chemotactic protein 1 (MCP 1); Monocyte secretory protein JE; Small inducible cytokine A2 Immunogen Recombinant Protein Accession P13500 Clone Number SDT 1737 66 Antibody Type Recombinant mAb Isotype IgG Application Sandwich ELISA Reactivity Hu Cross Reactivity No
Product Specification
| Host | Rabbit |
| Antigen | CCL2/MCP-1 |
| Synonyms | C-C motif chemokine 2; HC11; Monocyte chemoattractant protein 1; Monocyte chemotactic and activating factor (MCAF); Monocyte chemotactic protein 1 (MCP-1); Monocyte secretory protein JE; Small-inducible cytokine A2 |
| Immunogen | Recombinant Protein |
| Accession | P13500 |
| Clone Number | SDT-1737-66 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | Sandwich ELISA |
| Reactivity | Hu |
| Cross Reactivity | No cross reactivity with GRO alpha/CXCL1, GRO beta/CXCL2, IL-8 |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Purity | >95% by HPLC |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt, 2 to 8 °C as supplied |
Background
CCL2, also known as monocyte chemoattractant protein-1 (MCP-1), is a small cytokine belonging to the CC chemokine family. It is primarily secreted by monocytes, macrophages, and dendritic cells, and plays a crucial role in recruiting monocytes, memory T cells, and dendritic cells to sites of inflammation or tissue injury. CCL2 exerts its effects by binding to its receptor, CCR2, and is involved in various biological processes, including leukocyte chemotaxis, regulation of apoptosis, and modulation of immune responses. This chemokine is also implicated in several diseases, such as atherosclerosis, rheumatoid arthritis, cancers and neurodegenerative disorders, due to its role in promoting inflammation and immune cell infiltration. In conclusion, CCL2 is a multifunctional chemokine with significant roles in inflammation, fibrosis, and cancer. Its expression is tightly regulated and serves as a critical mediator of immune cell recruitment and activation. The diagnostic and therapeutic potential of CCL2 makes it a promising target for addressing a wide range of diseases. Further research into the mechanisms of CCL2 regulation and its interactions with the tumor microenvironment will likely yield new insights and therapeutic strategies.
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