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Description
IL13RA2/IL13R Fc Chimera Protein, HumanProduct Specification Species Human Synonyms IL 13 receptor subunit alpha 2, IL 13R subunit alpha 2, IL 13R alpha 2, IL 13RA2, nterleukin 13 binding protein, Interleukin 13 receptor subunit alpha 2, IL13RA2 Accession Q14627 Amino Acid Sequence Asp27 Arg343, with C terminal hIgG1 Fc Expression System HEK293 Molecular Weight 73 89kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag Human Fc Tag Physical Appearance
Product Specification
| Species | Human |
| Synonyms | IL-13 receptor subunit alpha-2, IL-13R subunit alpha-2, IL-13R-alpha-2, IL-13RA2, nterleukin-13-binding protein, Interleukin-13 receptor subunit alpha-2, IL13RA2 |
| Accession | Q14627 |
| Amino Acid Sequence | Asp27-Arg343, with C-terminal hIgG1 Fc |
| Expression System | HEK293 |
| Molecular Weight | 73-89kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | Human Fc Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage |
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | Kawakami K, Kawakami M, Puri R. Specifically targeted killing of interleukin-13 (IL-13) receptor-expressing breast cancer by IL-13 fusion cytotoxin in animal model of human disease. Mol Cancer Ther. 2004; 3:137–147. Valverde A, Povedano E, Montiel V, Yanez-Sedeno P, Garranzo-Asensio M, Barderas R, Campuzano S, Pingarron J. Electrochemical immunosensor for IL-13 Receptor alpha2 determination and discrimination of metastatic colon cancer cells. Biosens Bioelectron. 2018; 117:766–772. Okamoto H, Yoshimatsu Y, Tomizawa T, Kunita A, Takayama R, Morikawa T, Komura D, Takahashi K, Oshima T, Sato M, Komai M, Podyma-Inoue K, Uchida H, Hamada H, Fujiu K, Ishikawa S, Fukayama M, Fukuhara T, Watabe T. Interleukin-13 receptor alpha2 is a novel marker and potential therapeutic target for human melanoma. Sci Rep. 2019; 9:1281. Husain S, Puri R. Interleukin-13 receptor-directed cytotoxin for malignant glioma therapy: from bench to bedside. J Neurooncol. 2003; 65:37–48. Tu M, Wange W, Cai L, Zhu P, Gao Z, Zheng W. IL-13 receptor alpha2 stimulates human glioma cell growth and metastasis through the Src/PI3K/Akt/mTOR signaling pathway. Tumour Biol. 2016; 37:14701–14709. D.D. Donaldson, M.J. The murine IL-13 receptor alpha 2: molecular cloning, characterization, and comparison with murine IL-13 receptor alpha 1. J. Immunol., 161 (1998), pp. 2317-2324 |
Background
Interleukin-13 receptor subunit alpha-2 (IL13RA2) is a high-affinity membrane receptor of IL-13 and is abundantly expressed in a variety of tumors, such as pancreatic cancer, ovarian cancer, breast cancer, colon cancer and melanoma. IL13RA2 is a glycosylated protein containing four potential glycosylation sites. IL13RA2 was initially considered a second, decoy receptor for interleukin 13 (IL-13). IL13RA2 is upregulated during helminthic and parasitic infections (i.e. schistosomiasis) as IgE is a key molecule in the fight against parasites and IL-13 is required for the IgE switching. A IL13RA2, an immunotherapeutic target, is considered a promising direction for the treatment of glioma.
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