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Description
Lamin A/C Recombinant Rabbit mAb (PE Conjugate) (SDT-R041)Product Specification Host Rabbit Antigen Lamin A C Synonyms Prelamin A C, 70 kDa lamin, Renal carcinoma antigen NY REN 32 Accession P02545 Clone Number SDT R041 Antibody Type Recombinant mAb Isotype IgG Application ICFCM Reactivity Hu Positive Sample HeLa Purification Protein A Concentration 1 mg ml Conjugation PE Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0. 3% Proclin 300 Stability & Storage 12 months from date of receipt
Product Specification
| Host | Rabbit |
| Antigen | Lamin A/C |
| Synonyms | Prelamin-A/C, 70 kDa lamin, Renal carcinoma antigen NY-REN-32 |
| Accession | P02545 |
| Clone Number | SDT-R041 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | ICFCM |
| Reactivity | Hu |
| Positive Sample | HeLa |
| Purification | Protein A |
| Concentration | 1 mg/ml |
| Conjugation | PE |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| ICFCM | 1:1000 | Hu |
Background
Lamins are a class of intermediate filament proteins that form a matrix on the inner surface of the nuclear envelope. These proteins are found in many different cell types in three different forms (A, B, and C). Lamins A and C are alternatively spliced versions of the LMNA gene. Lamin A has a mass of about 74kDa while Lamin C is 65kDa. Mutations in the LMNA gene are associated with several serious human diseases, including Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease type 2B1, and Hutchinson-Gilford progeria syndrome.
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