Pay in installments of $10.00 with
,
and
Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Aug 29 - Sep 3
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
Mouse Anti-Rat CD28 Antibody (S-3929)Product Specification Host Mouse Antigen CD28 Synonyms T cell specific surface glycoprotein CD28; Cd28 Location Cell membrane Accession P31042 Clone Number S 3929 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Rt Positive Sample SD Rat splenocytes Purification Protein G Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4 Stability & Storage 12 months from date of receipt
Product Specification
| Host | Mouse |
| Antigen | CD28 |
| Synonyms | T-cell-specific surface glycoprotein CD28; Cd28 |
| Location | Cell membrane |
| Accession | P31042 |
| Clone Number | S-3929 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Rt |
| Positive Sample | SD Rat splenocytes |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1:200 | Rt |
Background
CD28 is a critical costimulatory receptor constitutively expressed on the surface of naïve T cells that, upon binding the ligands CD80 or CD86 on antigen-presenting cells, delivers an indispensable second signal that synergizes with TCR engagement to trigger full T-cell activation, proliferation, cytokine production (especially IL-2), metabolic reprogramming and survival by recruiting PI3K, GRB2/GADS and Lck to phosphorylate downstream effectors such as Akt, PKCθ and NF-κB, and its blockade or absence leads to anergy, whereas its engineered inclusion in CAR-T cells or therapeutic agonism is exploited to enhance anti-tumor immunity.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy