SKU: 56639137469

UniOne® TR-FRET Human BCL-XL/VHL PROTAC Binding Kit

$981.00 $1090.00
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Description

UniOne® TR-FRET Human BCL-XL/VHL PROTAC Binding KitProduct Specification Host Human Stability & Storage 80 Background This kit uses HomogeneousTime Resolved Fluorescence (TR FRET) technology to measure the molecular glueBCL XL DEGRADER 2 and test compound mediated interaction between VHL andBCL XL. This method enables a simple and rapid high throughput format for screeningsmall molecules that can mediate the interaction between VHL and BCL XL. As shown, the interaction betweenVHL and BCL XL is

Product Specification


Host Human
Stability & Storage

-80℃

Background

This kit uses HomogeneousTime-Resolved Fluorescence (TR-FRET) technology to measure the molecular glueBCL-XL DEGRADER-2 and test compound-mediated interaction between VHL andBCL-XL. This method enables a simple and rapid high-throughput format for screeningsmall molecules that can mediate the interaction between VHL and BCL-XL.

As shown, the interaction betweenVHL and BCL-XL is detected using an Eu-labeled anti-Tag1 antibody (TR-FRETdonor) and an Acceptor-labeled anti-Tag2 antibody (TR-FRET acceptor). Since themolecular glue BCL-XL DEGRADER-2 mediates the interaction between VHL andBCL-XL, the donor and acceptor antibodies are brought into proximity.Excitation of the donor antibody triggers Fluorescence Resonance EnergyTransfer (FRET) to the acceptor antibody, resulting in a specific emissionsignal at 665 nm from the acceptor. This specific signal is proportional to thedegree of interaction mediated by BCL-XL DEGRADER-2 between VHL and BCL-XL.This homogeneous assay is simple to perform and requires no washing steps.



Components

Table 1. Reagents and Storage Conditions

Component

Concentration

100TESTS

500TESTS

2500TESTS

10000TESTS

Storage Temp.

Tag1-VHL protein

50×

10μL

40μL

200μL

800μL

-80°C

Tag2- BCL-XL protein

50×

10μL

40μL

200μL

800μL

-80°C

BCL-XL DEGRADER-2

0.3 mM

5μL

20μL

50μL

200μL

-80°C

Anti-Tag1 Eu dye antibody

50×

10μL

50μL

250μL

1000μL

-80°C

Anti-Tag2 AC antibody

100×

5μL

25μL

125μL

500μL

-80°C

Detection buffer

10×

400μL

2 mL

10 mL

40 mL

-80°C

*Reagents should be avoided from repeated freeze-thaw cycles. Aliquot upon first thaw and store under recommended conditions. Valid for one year.

Shipping Notes
  • Free Standard Shipping on $100+ Orders to the USA.
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Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
  • Final sale items are not eligible for returns or exchanges.
  • To process your return/exchange, please contact us at [email protected]
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SKU: 56639137469

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4.6 ★★★★★
Based on 12 reviews
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G
Verified Purchase
G. M.
Louisville, US
★★★★★ 5
Super usefull
Color: pink
If you're in search of a stylish and functional way to organize your jewelry while on-the-go, then this pink travel jewelry organizer is definitely worth considering. With its compact design and thoughtful features, it's the perfect accessory for any traveler or jewelry lover. One of the standout features of this organizer is its size. With a compact design that can easily fit into a purse or suitcase, it's perfect for taking your jewelry with you on the go. And despite its small size, it still offers plenty of storage options - from compartments for necklaces and bracelets to slots for rings and earrings, it can hold all of your essential pieces. But beyond its size, this travel jewelry organizer is also incredibly stylish. The soft pink color adds a feminine touch, while the sleek design and gold-tone hardware give it a sophisticated look. It's the perfect accessory to carry with you on any trip or to use as a daily storage option for your jewelry. Another great feature of this organizer is its thoughtful design. The compartments and slots are all padded to protect your jewelry from scratches and damage, while the zippered closure ensures that everything stays secure and in place. Plus, the compact design means that you won't have to worry about your jewelry getting tangled or jumbled together during travel. Overall, if you're in need of a travel jewelry organizer that is both stylish and functional, this pink option is definitely worth considering. With its compact size, ample storage options, and thoughtful design features, it's a great investment that will help you keep your jewelry organized and protected while on the go.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 22, 2023
K
Verified Purchase
Kevin
Boise, US
★★★★★ 5
Nice and Elegant.
Size: 7.7" x 7.7" x 1.7", Color: Black (Metal Glided), Size: 7.7" x 7.7" x 1.7", Color: Black (Metal Glided)
Color looks great, material is good quality and fits most of my items. It makes my items look neat and organized. Price is a bit high but worth it in my opinion.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on January 22, 2026
L
Verified Purchase
Lana T
Boise, US
★★★★★ 5
Quite nice and very functional
Size: 7.7" x 7.7" x 1.7", Color: Grey (Metal Silvered), Size: 7.7" x 7.7" x 1.7", Color: Grey (Metal Silvered)
Elegant and substantial - this valet catch all for your night stand or dresser is quite nice and very sophisticated. Sleek and soft brushed suede like material. It was packed well, and is quite nice to keep miscellaneous items corralled together. I’m very pleased and would recommend.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 15, 2025
C
Verified Purchase
Cali Mom
Bozeman, US
★★★★★ 5
Perfect size, high quality
Size: 7.7" x 7.7" x 1.7", Color: Black (Metal Silvered)
I had a previous catch all tray that I bought on amazon, it used buttons on the 4 corners to turn a flat cardboard into a tray. Over time, the catch all tray got filled up, not just with a wallet, keys and eyeglasses but eventually business cards and other knick knacks. With all the items inside the tray, sometimes the buttons would start to pop out. It wasn't awful, more of an annoyance. But it was time for me to find a more durable tray. I looked on amazon and added 6 different trays that had "potential" into my shopping cart. Then I carefully evaluated each one and deleted them out of my cart until there was only one left. Some had multiple compartments. Some were larger than this one. I felt the ones with compartments would limit my ability to put the things I want in there. Also, I didn't want it so big that it took up too much desk space. Ultimately, I felt this was the perfect size. I'm extremely happy with it, the quality is really nice and it looks and feels durable. No more loose buttons and spilled knick knacks.
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Reviewed in the United States on October 14, 2024
D
Verified Purchase
Denise
Battle Creek, US
★★★★★ 5
Keeps clutter away
Size: 7.7" x 7.7" x 1.7", Color: Black (Metal Silvered)
This works great to corral all my notes I write on post its or small notes. Keeping them hidden from the desk top b/c or the depth but still visible to me. Much better than keeping on the plotter. Looks great in quality .
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on October 25, 2025

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