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Description
BAFF Protein, HumanProduct Specification Species Human Synonyms Tumor necrosis factor ligand superfamily member 13B, B lymphocyte stimulator (BLyS), B cell activating factor, BAFF, Dendritic cell derived TNF like molecule, TNF and APOL related leukocyte expressed ligand 1 (TALL 1) Accession Q9Y275 Amino Acid Sequence Ala134 Leu285 Expression System HEK293 Molecular Weight 16 24 kDa (Reducing) Purity >95% by SDS PAGE Endotoxin <0. 01EU g Conjugation Unconjugated Tag No
Product Specification
| Species | Human |
| Synonyms | Tumor necrosis factor ligand superfamily member 13B, B lymphocyte stimulator (BLyS), B-cell-activating factor, BAFF, Dendritic cell-derived TNF-like molecule, TNF- and APOL-related leukocyte expressed ligand 1 (TALL-1) |
| Accession | Q9Y275 |
| Amino Acid Sequence | Ala134-Leu285 |
| Expression System | HEK293 |
| Molecular Weight | 16-24 kDa (Reducing) |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.01EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Nature. 2000 Apr 27;404(6781):995-9. |
Background
B-cell activating factor (BAFF), also known as B lymphocyte stimulator (BLyS), is a cytokine that belongs to the tumor necrosis factor (TNF) ligand superfamily and plays a crucial role in regulating B-cell development, survival, and function. In humans, BAFF is primarily produced by myeloid cells, including monocytes, macrophages, and dendritic cells, and acts on B cells through binding to its receptors, BAFF-R, TACI, and BCMA. By engaging these receptors, BAFF promotes the survival, maturation, and antibody production of B cells, as well as the formation of germinal centers and the maintenance of peripheral B-cell populations. Dysregulation of BAFF signaling has been implicated in various autoimmune diseases, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis, highlighting the importance of BAFF in immune homeostasis and autoimmunity.
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