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Description
PI3 Kinase p85α Recombinant Rabbit mAb (S-328-24)Product Specification Host Rabbit Antigen PI3 Kinase p85 Synonyms Phosphatidylinositol 3 kinase regulatory subunit alpha, PI3 kinase regulatory subunit alpha, PI3K regulatory subunit alpha, PtdIns 3 kinase regulatory subunit alpha, PI3 kinase subunit p85 alpha, PtdIns 3 kinase regulatory subunit p85 alpha, PIK3R1 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus, Membrane Accession P27986 Clone Number S 328 24 Antibody Type Rabbit mAb
Product Specification
| Host | Rabbit |
| Antigen | PI3 Kinase p85α |
| Synonyms | Phosphatidylinositol 3-kinase regulatory subunit alpha, PI3-kinase regulatory subunit alpha, PI3K regulatory subunit alpha, PtdIns-3-kinase regulatory subunit alpha, PI3-kinase subunit p85-alpha, PtdIns-3-kinase regulatory subunit p85-alpha, PIK3R1 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus, Membrane |
| Accession | P27986 |
| Clone Number | S-328-24 |
| Antibody Type | Rabbit mAb |
| Application | WB, IHC-P, ICC, ICFCM, IP |
| Reactivity | Hu, Ms, Rt |
| Predicted Reactivity | Or, Bv |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | |
| IP | 1:50 | |
| IHC | 1:250 | |
| ICFCM | 1:500 | |
| ICC | 1:500 |
Background
Cell proliferation and many other cell processes can be regulated through a signaling pathway that involves an enzyme called PI3K. This ‘heterodimeric’ enzyme is made up of two protein subunits, one of which is called p85α and inhibits the other subunit of the enzyme (known as p110) to prevent uncontrolled cell proliferation. Activation of the class 1A PI3K is gated, in part, by the p85α regulatory subunit, which contains a Src homology 3 (SH3) domain, two proline-rich (PR) regions (PR1 and PR2) separated by a Rho-GAP/BCR-homology (BH) domain, and two Src homology 2 (SH2) domains (nSH2, cSH2) flanking an inter-SH2 (iSH2) domain [PMID: 26222500].
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