SKU: 56892176381

Invivo Anti-Mouse IL-4 Recombinant mAb

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Ships within 48 hours · Estimated delivery Aug 29 - Sep 3

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Description

Invivo Anti-Mouse IL-4 Recombinant mAbProduct Specification Host Rat Antigen IL 4 Synonyms Interleukin 4; B cell IgG differentiation factor; B cell growth factor 1; B cell stimulatory factor 1 (BSF 1); IGG1 induction factor; Lymphocyte stimulatory factor 1; Il 4; Il4 Location Secreted Accession P07750 Clone Number S 3840 Antibody Type Rat mAb Isotype Rat IgG1,k Application ELISA, WB, in vivo IL 4 neutralization, in vitro IL 4 neutralization, in vivo IL 4 receptor stimulation (as a complex

Product Specification


Host Rat
Antigen IL-4
Synonyms Interleukin-4; B-cell IgG differentiation factor; B-cell growth factor 1; B-cell stimulatory factor 1 (BSF-1); IGG1 induction factor; Lymphocyte stimulatory factor 1; Il-4; Il4
Location Secreted
Accession P07750
Clone Number S-3840
Antibody Type Rat mAb
Isotype Rat IgG1,k
Application ELISA, WB, in vivo IL-4 neutralization, in vitro IL-4 neutralization, in vivo IL-4 receptor stimulation (as a complex with IL-4)
Purification Protein G
Concentration 5 mg/ml
Purity >95%(Determined by SDS-PAGE)
Endotoxin <1EU/mg
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS pH7.4, containing no preservative

Stability & Storage

2 to 8 °C for 2 weeks under sterile conditions;
-20 °C for 3 months under sterile conditions;
-80 °C for 24 months under sterile conditions.
Please avoid repeated freeze-thaw cycles.

Dilution


application dilution species
WB 1:1000-1:50000 Ms

Background

Interleukin-4 (IL-4) is a 15–20 kDa, glycosylated, four-α-helical cytokine secreted primarily by Th2-polarized CD4⁺ T cells, mast cells, basophils and eosinophils that signals through a heterodimeric receptor complex composed of the IL-4Rα chain paired with either the common γ chain (type I, hemopoietic cells) or the IL-13Rα1 chain (type II, non-hemopoietic cells) to activate JAK1/3–STAT6 and IRS1/2 pathways, thereby driving commitment of naïve CD4⁺ T cells to the Th2 lineage, promoting immunoglobulin class-switching to IgG1 and IgE in B cells, inducing alternative activation (M2) of macrophages that orchestrate tissue repair and fibrosis, stimulating mucus production and smooth muscle remodeling in airway epithelium, and acting as a central mediator of allergic inflammation, asthma pathogenesis and resistance to helminth parasites, while also exerting context-dependent anti-inflammatory effects that limit Th1/Th17 responses and autoimmune damage.

Shipping Notes
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Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
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SKU: 56892176381

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4.6 ★★★★★
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Tasha U
Birmingham, US
★★★★★ 5
Good quality dog ball for playing fetch
Size: Medium
My dog and family love these chuck it balls to play fetch with our dog. They are durable and fun. They squeak which is added fun for any dog! Regular tennis balls my dog chews apart and they get pretty gross after playing and being left outside. These can be easily washed off and cleaned. These balls last! Would recommend to anyone with a dog and would purchase again.
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Reviewed in the United States on April 17, 2025
R
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ryan johnson
Boise, US
★★★★★ 5
Tough and sturdy
Size: Medium
Have lasted my dog for years now and she is a tough chewer. Worth the money
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Reviewed in the United States on December 12, 2025
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Verified Purchase
VegasHawkeye
New York, US
★★★★★ 5
Picky dog approved!
Color: S6-muti-color, Color: S6-muti-color
I have wasted so much money on dog balls that they won't even pick up! They finally were obsessed with the Kong rubber green/blue or red/blue ones, but they're $3+. each, and they break from the dogs squishing it. I honestly had zero expectations on these, and they BOTH picked them up on the first throw! That's huge!! Seem to work fine in the ChuckIt. As for the squeaker, at first I was like "Oh nooooo." when they both loudly started! Much to my (and my neighbors') happiness, the squeakers stopped working after a couple minutes. 🤣
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Reviewed in the United States on February 2, 2025
W
Verified Purchase
William Lovelace
Lexington, US
★★★★★ 5
Great dog toys
Color: S6-muti-color
These are long lasting, durable dog toys. My dogs love the squeak sound.
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Reviewed in the United States on May 23, 2026
K
Verified Purchase
Karen
Lowell, US
★★★★★ 5
Durable
Color: S6-muti-color
The balls are great for chewers. The squeaky didn’t last long but they are perfect for the ball launcher.
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Reviewed in the United States on May 18, 2026

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