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Description
Calnexin Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen Calnexin Synonyms IP90; Major histocompatibility complex class I antigen binding protein p88; p90; CANX Immunogen Synthetic Peptide Location Endoplasmic reticulum Accession P27824 Antibody Type Polyclonal antibody Isotype IgG Application WB, IHC P, ICC Reactivity Hu Positive Sample HeLa, U 2 OS, MCF7, THP 1, SH SY5Y, HepG2, LNCaP Purification Immunogen Affinity Concentration 0. 5 mg ml Conjugation Unconjugated
Product Specification
| Host | Rabbit |
| Antigen | Calnexin |
| Synonyms | IP90; Major histocompatibility complex class I antigen-binding protein p88; p90; CANX |
| Immunogen | Synthetic Peptide |
| Location | Endoplasmic reticulum |
| Accession | P27824 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu |
| Positive Sample | HeLa, U-2 OS, MCF7, THP-1, SH-SY5Y, HepG2, LNCaP |
| Purification | Immunogen Affinity |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:2000 | Hu |
| IHC-P | 1:250 | Hu |
| ICC | 1:500 | Hu |
Background
Calnexin is an integral endoplasmic reticulum (ER) type I transmembrane lectin chaperone that transiently binds newly synthesized monoglucosylated N-glycoproteins through its luminal carbohydrate-binding domain, coordinates sequential folding events with the oxidoreductase ERp57 to form disulfide bonds, retains incompletely folded or misassembled polypeptides in the ER via a cytosolic phosphorylation-regulated retrieval motif that interacts with the Sec61 translocon, and thereby serves as a central quality-control checkpoint that prevents aggregation and premature trafficking, while also participating in ER calcium homeostasis and cellular stress responses such as the unfolded protein response (UPR).
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