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Description
GLP1R full length Flag&His Tag Protein,HumanProduct Specification Species Human Synonyms GLP 1; GLP 1 R; GLP 1R Accession P43220 Concentration 1. 08 mg ml Amino Acid Sequence R24 F257, E262 K437, S193C, I196F, S225A, M233C, S271A, I317C, G318I, G361C, K346A, C347F, E387D Expression System Baculovirus InsectCells Molecular Weight 57. 3KDa Endotoxin <1EU g Conjugation Unconjugated Tag His Tag, Flag Tag Physical Appearance Liquid Storage Buffer 20 mM HEPES pH 7. 5, 150 mM NaCl, 0. 05% (w v) GDN,
Product Specification
| Species | Human | |
| Synonyms | GLP-1; GLP-1-R; GLP-1R | |
| Accession | P43220 | |
| Concentration | 1.08 mg/ml | |
| Amino Acid Sequence | R24-F257, E262-K437, S193C, I196F, S225A, M233C, S271A, I317C, G318I, G361C, K346A, C347F, E387D |
|
| Expression System | Baculovirus-InsectCells | |
| Molecular Weight | 57.3KDa | |
| Endotoxin | <1EU/μg | |
| Conjugation | Unconjugated | |
| Tag | His Tag, Flag Tag | |
| Physical Appearance | Liquid | |
| Storage Buffer | 20 mM HEPES pH 7.5, 150 mM NaCl, 0.05% (w/v) GDN, 0.005% (w/v) CHS. | |
| Stability & Storage |
|
Background
A 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants.
Guidelines
For complete recovery, mix well and spin before use.
Product must not be store in diluted solutions.
Aliquots below 10l are not advisable.
Avoid repetitive freeze-thaw cycles!
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Exchange/Return Notes
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