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Description
IL-31 His Tag Protein, HumanProduct Specification Species Human Accession Q6EBC2 Amino Acid Sequence Ser24 Thr164, with N His Tag Expression System HEK293 Molecular Weight Predicted MW: 17. 5 kDa Observed MW: 20 kDa Purity >95% by SDS PAGE Endotoxin <1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized powder Storage Buffer 0. 2M PBS, pH7. 4 with 3% trehalose. Reconstitution Reconstitute no more than 1 mg mL according to the size in deionized water after
Product Specification
| Species | Human |
| Accession | Q6EBC2 |
| Amino Acid Sequence | Ser24-Thr164, with N-His Tag |
| Expression System | HEK293 |
| Molecular Weight | Predicted MW: 17.5 kDa Observed MW: 20 kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | 0.2M PBS, pH7.4 with 3% trehalose. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage |
|
Background
Interleukin-31 (IL-31) is a novel cytokine belonging to the IL-6 family, primarily produced by activated T helper 2 (Th2) cells and mast cells. It signals through a heterodimeric receptor composed of IL-31 receptor A (IL-31RA) and oncostatin M receptor β (OSMRβ), which is expressed on various cell types including sensory neurons, keratinocytes, and immune cells. IL-31 is a key mediator of pruritus (itch) in inflammatory skin diseases such as atopic dermatitis, psoriasis, and allergic conditions. Its signaling pathway promotes itch sensation, disrupts epidermal barrier function, and drives immune responses, making it a significant therapeutic target for chronic pruritic disorders.
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