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Description
Mouse Anti-Rat MHC II (RT1D) Antibody (S-R649)Product Specification Host Mouse Antigen MHC II (RT1D) Location Membrane Accession Q31281 Clone Number S R649 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Rt Positive Sample Lewis Rat splenocytes Purification Protein G Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4 Stability & Storage 12 months from date of receipt reconstitution, 2 to 8 C as supplied. Dilution application
Product Specification
| Host | Mouse |
| Antigen | MHC II (RT1D) |
| Location | Membrane |
| Accession | Q31281 |
| Clone Number | S-R649 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Rt |
| Positive Sample | Lewis Rat splenocytes |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 1:2000 | Rt |
Background
MHC II (Major Histocompatibility Complex Class II) proteins are a class of cell surface molecules expressed by antigen-presenting cells (such as dendritic cells, macrophages, and B cells). They are responsible for presenting exogenous antigenic peptides to CD4+ T helper cells, thereby initiating adaptive immune responses. MHC II molecules consist of two transmembrane chains (α and β) that form a peptide-binding groove, which binds and displays antigenic peptides derived from extracellular pathogens or proteins. Their expression is regulated by immune modulators (such as IFN-γ) and plays a critical role in autoimmune diseases, transplant rejection, and infection immunity. The diversity of MHC II is encoded by highly polymorphic genes, ensuring a broad capacity for antigen recognition, making it a core mechanism of the immune system for identifying and eliminating pathogens.
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