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Description
PRAME Recombinant Rabbit mAb (S-1876-173)Product Specification Host Rabbit Antigen PRAME Synonyms Melanoma antigen preferentially expressed in tumors; Opa interacting protein 4 (OIP 4); Preferentially expressed antigen of melanoma; MAPE; OIP4 Immunogen Recombinant Protein Location Cell membrane, Cytoplasm, Nucleus Accession P78395 Clone Number S 1876 173 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC Reactivity Hu Positive Sample A375, U 2 OS, K562, SK MEL 2 Purification
Product Specification
| Host | Rabbit |
| Antigen | PRAME |
| Synonyms | Melanoma antigen preferentially expressed in tumors; Opa-interacting protein 4 (OIP-4); Preferentially expressed antigen of melanoma; MAPE; OIP4 |
| Immunogen | Recombinant Protein |
| Location | Cell membrane, Cytoplasm, Nucleus |
| Accession | P78395 |
| Clone Number | S-1876-173 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ICC |
| Reactivity | Hu |
| Positive Sample | A375, U-2 OS, K562, SK-MEL-2 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| ICC | 1:500 | Hu |
Background
PRAME (Preferentially Expressed Antigen of Melanoma) is a protein encoded by the PRAME gene, belonging to the cancer-testis antigen family. It is predominantly expressed in various cancers, including melanoma, breast cancer, lung cancer, and leukemia, but is largely absent in normal tissues except for testis, ovary, placenta, and a few others. PRAME can inhibit retinoic acid signaling, thereby promoting cell proliferation and contributing to tumorigenesis. Due to its restricted expression pattern, PRAME is considered a promising target for cancer immunotherapy, with ongoing research exploring PRAME-specific vaccines and cellular immunotherapies.
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