SKU: 58240844748

ALK Recombinant Rabbit mAb,PBS Only (SDT-3284)

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Description

ALK Recombinant Rabbit mAb,PBS Only (SDT-3284)Product Specification Host Rabbit Antigen ALK Synonyms ALK tyrosine kinase receptor; Anaplastic lymphoma kinase; CD246 Location Cell membrane Accession Q9UM73 Clone Number SDT 3284 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu Positive Sample SH SY5Y, IMR 32 Purification Protein A Concentration 1mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS Stability & Storage 12 months from date of

Product Specification


Host Rabbit
Antigen ALK
Synonyms ALK tyrosine kinase receptor; Anaplastic lymphoma kinase; CD246
Location Cell membrane
Accession Q9UM73
Clone Number SDT-3284
Antibody Type Recombinant mAb
Isotype IgG
Application WB, IHC-P
Reactivity Hu
Positive Sample SH-SY5Y, IMR-32
Purification Protein A
Concentration 1mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS

Stability & Storage

12 months from date of receipt / reconstitution, 4 °C as supplied

Dilution


application dilution species
WB 1:1000 Hu
IHC-P 1:250 Hu

Background

Anaplastic lymphoma kinase (ALK), also designated CD246, is a single-pass transmembrane receptor tyrosine kinase of the insulin-receptor superfamily that is normally expressed at highest levels in the developing and adult nervous system, where it regulates neuronal differentiation, axon guidance and cognition; the 1620-aa glycoprotein presents an N-terminal extracellular region containing two MAM domains and an LDL-A module for ligand binding, a single hydrophobic transmembrane segment and a C-terminal cytoplasmic kinase domain that, upon ligand-induced dimerization, undergoes trans-autophosphorylation and triggers RAS–MAPK, PI3K–AKT and JAK–STAT signaling cascades controlling cell proliferation and survival. Chromosomal translocations (most famously t(2;5)(p23;q35) producing NPM1–ALK), inversions (EML4–ALK in non-small-cell lung cancer) or activating point mutations cause constitutive kinase activity, driving malignant transformation in anaplastic large-cell lymphoma, subsets of NSCLC, neuroblastoma and inflammatory myofibroblastoma, making the oncoprotein a validated therapeutic target for small-molecule inhibitors such as crizotinib, alectinib and lorlatinib.

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SKU: 58240844748

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4.5 ★★★★★
Based on 28 reviews
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Verified Purchase
Soan Esteves
Los Angeles, US
★★★★★ 5
Great for fast frothing!!!
Color: Black
Very easy to use, the speed is fast enough for that little bit of froth in seconds, good for the price, battery lasts for days,
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Reviewed in the United States on May 13, 2026
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Tonya
West Palm Beach, US
★★★★★ 3
One speed level
Color: Black
The product currently operates at a single speed. While its performance is satisfactory, there is no option to reduce the speed. We kindly request the addition of an additional speed level for this item. 😒
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Reviewed in the United States on March 2, 2026
H
Verified Purchase
happycurls
New York, US
★★★★★ 5
Reliable favorite kitchen tool
Color: Blue
This wonderful tool may be the most used tool in our kitchen. The hardest thing about it is to remember you can push the button and it runs- you don't have to hold it!. The charge on the rechargable battery last a long time- about 1 recharge per month- and we use it daily. We use the mixer attachment most. It works great for protein powders, collagen, iced tea or lemonade mix. It cleans easily and is waterproof- just make sure the cover is over the charging port. We have used it to froth milk, whip eggs, and as I said we use it daily to mix beverages. I worried about the price, but it is a great value because we bought it in December 2024 and it is more powerful and has already lasted longer than two whimpy ones.
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Reviewed in the United States on October 28, 2025
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Verified Purchase
Link
Massapequa, US
★★★★★ 5
Quality
Color: Black
This is by far the best frother I've used. Battery life is great. Its UX is excellent. Feels nice in the hand and has great power. Also like the on/off button as opposed to haveing to hold a switch down. Looking forward to getting their s3 scale.
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Reviewed in the United States on April 11, 2026
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Verified Purchase
Sonya the vet
Alexandria, US
★★★★★ 4
Overall good frother
Color: Black
Bought the Maestri and the Zulay frother to test which one is better since both had good reviews. Returned the Zulay (see Zulay review) and kept the Maestri. Been using it for a few days now and works well. Mixes chai and hot chocolate well. It has one speed that is a good speed to mix, but not so fast that it causes the drink to spill over the top as long as the cup is filled to about 80% full. Because I tend to use the tall 20 oz Contigo autoseal cups, it could benefit from offering longer attachments to reach the bottom of the cup (note: that I did not find any company that offers longer attachment arms).
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Reviewed in the United States on January 28, 2026

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