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Description
TDG Recombinant Rabbit mAb (S-3111-16)Product Specification Host Rabbit Antigen TDG Synonyms G T mismatch specific thymine DNA glycosylase; Thymine DNA glycosylase (hTDG) Immunogen Synthetic Peptide Location Nucleus Accession Q13569 Clone Number S 3111 16 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu Positive Sample 293T, HeLa, K562, Jurkat, HCT 116 Purification Protein A Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage
Product Specification
| Host | Rabbit |
| Antigen | TDG |
| Synonyms | G/T mismatch-specific thymine DNA glycosylase; Thymine-DNA glycosylase (hTDG) |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | Q13569 |
| Clone Number | S-3111-16 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu |
| Positive Sample | 293T, HeLa, K562, Jurkat, HCT 116 |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:50 | Hu |
Background
TDG (thymine DNA glycosylase) is a 410-residue nuclear enzyme that belongs to the uracil DNA glycosylase (UDG) superfamily and acts as a key guardian of epigenetic stability by excising thymine, 5-formylcytosine, 5-carboxylcytosine and other deaminated or oxidized bases from G•T, G•U or G•5fC/5caC mispairs in double-stranded DNA, thereby initiating base-excision repair (BER), reshaping CpG methylation landscapes and preventing C→T transition mutations and transcriptional misregulation in embryonic stem cells and somatic tissues.
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