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Description
Alexa Fluor® 488 Mouse Anti-Human CD6 Antibody (S-3174)Product Specification Host Mouse Antigen CD6 Synonyms T cell differentiation antigen CD6; T12; TP120; CD6 Location Cell membrane Accession P30203 Clone Number S 3174 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample Human peripheral blood Leukocytes Purification Protein G Concentration 0. 2 mg ml Conjugation Alexa Fluor 488 Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0. 3% Proclin 300 Stability & Storage
Product Specification
| Host | Mouse |
| Antigen | CD6 |
| Synonyms | T-cell differentiation antigen CD6; T12; TP120; CD6 |
| Location | Cell membrane |
| Accession | P30203 |
| Clone Number | S-3174 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human peripheral blood Leukocytes |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 488 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1.25μl per million cells in 100μl volume | Hu |
Background
The mammalian target of rapamycin (mTOR) protein is a crucial serine/threonine kinase that plays a central role in regulating various cellular processes such as cell growth, proliferation, survival, and metabolism. It integrates signals from multiple pathways including nutrient availability, growth factors, and energy status to control protein synthesis, lipid metabolism, and autophagy. mTOR exists in two distinct complexes: mTORC1 and mTORC2. mTORC1, which is sensitive to rapamycin, is primarily involved in promoting protein synthesis by phosphorylating key substrates like S6K and 4E-BP1, thereby driving cell growth and division. It also inhibits autophagy when nutrients are abundant. mTORC2, on the other hand, regulates the actin cytoskeleton and cell survival by phosphorylating proteins such as Akt and PKC. Dysregulation of mTOR signaling is implicated in numerous diseases including cancer, diabetes, and neurodegenerative disorders, making it an important target for therapeutic interventions.
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Exchange/Return Notes
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