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Description
ATF3 Recombinant Rabbit mAb, PBS Only (SDT-4100)Product Specification Host Rabbit Antigen ATF3 Synonyms Cyclic AMP dependent transcription factor ATF 3; cAMP dependent transcription factor ATF 3; Activating transcription factor 3 Location Nucleus Accession P18847 Clone Number SDT 4100 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC, ChIP Reactivity Hu Positive Sample HepG2, 293T, HeLa, PMA & LPS treated THP 1 cells Purification Protein A Concentration 1 mg ml Conjugation
Product Specification
| Host | Rabbit |
| Antigen | ATF3 |
| Synonyms | Cyclic AMP-dependent transcription factor ATF-3; cAMP-dependent transcription factor ATF-3; Activating transcription factor 3 |
| Location | Nucleus |
| Accession | P18847 |
| Clone Number | SDT-4100 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC, ChIP |
| Reactivity | Hu |
| Positive Sample | HepG2, 293T, HeLa, PMA & LPS treated THP-1 cells |
| Purification | Protein A |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS |
| Stability & Storage | 12 months from date of receipt / reconstitution, 4 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:500 | Hu |
| ICC | 1:500 | Hu |
| ChIP | 1:20-1:50 | Hu |
Background
ATF3 (Activating Transcription Factor 3) is a 181-amino-acid stress-inducible bZIP transcription factor that binds DNA as homo- or heterodimer, recognized by the consensus TGACGTCA, and acts as a dual-function transcriptional regulator—repressing or activating target genes involved in apoptosis, inflammation, cell-cycle checkpoints, metabolic reprogramming and oncogenesis—rapidily up-regulated in response to hypoxia, DNA damage, cytokines, ER stress or mechanical strain, frequently overexpressed in cancers where it promotes survival, metastasis and chemoresistance yet can also function as a tumor suppressor depending on cellular context, and is subject to tight control via MAPK, NF-κB, p53 and multiple feedback loops, making it a critical node in integrating stress signals and determining cell fate.
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