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Description
Phospho - GSK-3α/β (Tyr216/279) Recombinant Rabbit mAb (S-1810-101)Product Specification Host Rabbit Antigen Phospho GSK 3 (Tyr216 279) Synonyms Glycogen synthase kinase 3 alpha; GSK 3 alpha; Serine threonine protein kinase GSK3A; GSK3A; Glycogen synthase kinase 3 beta; GSK 3 beta; Serine threonine protein kinase GSK3B; GSK3B Immunogen Synthetic Peptide Location Cytoplasm, Nucleus, Cell membrane Accession P49841 P49840 Clone Number S 1810 101 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Ms,
Product Specification
| Host | Rabbit |
| Antigen | Phospho - GSK-3α/β (Tyr216/279) |
| Synonyms | Glycogen synthase kinase-3 alpha; GSK-3 alpha; Serine/threonine-protein kinase GSK3A; GSK3A; Glycogen synthase kinase-3 beta; GSK-3 beta; Serine/threonine-protein kinase GSK3B; GSK3B |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus, Cell membrane |
| Accession | P49841、 P49840 |
| Clone Number | S-1810-101 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HeLa, mouse brain, rat brain |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| Dot Blot | 1:1000 | |
| WB | 1:1000-1:5000 | Hu, Ms, Rt |
Background
Phospho - GSK-3α/β (Tyr216/279) proteins are key players in cellular signaling pathways. Glycogen synthase kinase-3 (GSK-3) exists in two isoforms, α and β, and phosphorylation at specific tyrosine residues, such as Tyr216 in GSK-3β and Tyr279 in GSK-3α, can significantly impact their activity. This phosphorylation typically enhances the kinase activity of GSK-3, allowing it to regulate a wide range of biological processes including glycogen metabolism, gene transcription, and cell fate determination. Dysregulation of GSK-3 phosphorylation has been implicated in various diseases, making it an important target for therapeutic interventions.
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4.8 ★★★★★
Based on 8 reviews
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Product Reviews
★★★★★ 4
Wrinkles: Meh, KP: Yeah!
Style: MULTIBALM, Style: MULTIBALM
An okay moisturizer. Very shiny. Scent is old fashioned - kind of a floral baby powder scent. Takes a while to soak in which is by design since it only fills in the wrinkles instead of plumping them. The illusion is in the shine. You can see from my photos that in certain light the wrinkles appear slightly diminished due to the shine but you can clearly see they are still there in the shadows. While this example is on my hand, I had the same results under my eyes and on my forehead. I let the product soak in for 5 minutes in these photos. On the upside it worked temporary wonders on my KP!
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Reviewed in the United States on May 19, 2026
★★★★★ 5
From dry to soft in days.
Style: 3.38 Fl Oz (Non SPF)
I bought this moisturizer at a time when my skin truly needed help, with mature and sensitive skin, and I was dealing with intense dryness. My skin felt tight, dull, and uncomfortable, even after trying several products that didn’t provide lasting hydration.
I decided to try this cream and within the first few days, I noticed a real difference. It’s lightweight, absorbs quickly, doesn’t feel greasy, and most importantly, it doesn’t irritate my skin—instead, it soothes it. With continued use, my skin became softer, more supple, and visibly healthier, without that constant tight feeling.
I love that it’s fragrance-free, oil-free, and non-comedogenic, as it hasn’t caused any breakouts. It also contains ceramides and niacinamide, and the added SPF makes my routine much easier. After trying many products, I can honestly say this is the only one that truly worked for me. It’s now a daily essential.
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Reviewed in the United States on April 18, 2026
★★★★★ 5
The best
Style: 3.38 Fl Oz (Non SPF)
I’ve been using the La Roche-Posay Toleriane Double Repair Face Moisturizer for a few weeks now, and it’s honestly one of the best daily moisturizers I’ve tried—especially for sensitive skin.
First thing I noticed is how lightweight it feels. It absorbs quickly and doesn’t leave that greasy or heavy film that a lot of “hydrating” lotions do. My skin feels instantly softer, but not suffocated. It layers really well under makeup too—no pilling or weird texture.
What really stands out is how balanced my skin has been since using it. I tend to get dry patches but also occasional breakouts, and this somehow helps with both. It hydrates without clogging pores, and I’ve noticed less redness overall. The fact that it contains ceramides and niacinamide is a huge plus if you’re trying to repair your skin barrier.
It’s also fragrance-free, which I personally look for because anything scented tends to irritate my skin.
The only small downside is the price point compared to drugstore moisturizers, but honestly, a little goes a long way and the quality makes it worth it.
Overall, I’d definitely recommend this if you have sensitive, combination, or dry skin and want something simple but effective. It’s become a staple in my routine.
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Reviewed in the United States on April 20, 2026
★★★★★ 5
Great daily lotion
Style: 3.38 Fl Oz (Non SPF)
Great daily lotion. I love that it is light and fragrance free. It is perfect for day use. I have dry skin and sometimes it is not enough to use by itself. I mostly use it during the day as a base for sunscreen but it feels really good on the face and does not leave my face feeling greasy. The ingredients are really good and the value for money is great. I love LRP products and this is so easy to use.
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Reviewed in the United States on April 17, 2026
★★★★★ 5
✨ My New Favorite Face Cream for Hydrated & Glowing Skin ✨
Style: 3.38 Fl Oz (Non SPF)
“I’ve been using this La Roche-Posay cream for a few days now and I absolutely love it 😍💧 My skin feels super hydrated, soft, and has a healthy glow without any greasy residue. Plus, it’s perfect for sensitive skin because it feels light and soothing. My face feels so much fresher and more cared for ✨ I would definitely buy it again
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Reviewed in the United States on May 27, 2026
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