ADAMTS5 Recombinant Rabbit mAb (S-2315-138)
SKU: 60469707950

ADAMTS5 Recombinant Rabbit mAb (S-2315-138)

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Description

ADAMTS5 Recombinant Rabbit mAb (S-2315-138)Product Specification Host Rabbit Antigen ADAMTS5 Synonyms A disintegrin and metalloproteinase with thrombospondin motifs 5; ADAM TS 5; ADAM TS5; ADAMTS 5; A disintegrin and metalloproteinase with thrombospondin motifs 11 (ADAM TS 11; ADAMTS 11); ADMP 2; Aggrecanase 2; ADAMTS11; ADMP2 Immunogen Synthetic Peptide Location Secreted Accession Q9UNA0 Clone Number S 2315 138 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu Positive

Product Specification


Host Rabbit
Antigen ADAMTS5
Synonyms A disintegrin and metalloproteinase with thrombospondin motifs 5; ADAM-TS 5; ADAM-TS5; ADAMTS-5; A disintegrin and metalloproteinase with thrombospondin motifs 11 (ADAM-TS 11; ADAMTS-11); ADMP-2; Aggrecanase-2; ADAMTS11; ADMP2
Immunogen Synthetic Peptide
Location Secreted
Accession Q9UNA0
Clone Number S-2315-138
Antibody Type Recombinant mAb
Isotype IgG
Application WB
Reactivity Hu
Positive Sample HeLa, U-87 MG, HepG2, U-2 OS
Purification Protein A
Concentration 2 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:500-1:1000 Hu

Background

ADAMTS5 (A Disintegrin and Metalloproteinase with Thrombospondin Motifs 5), encoded on chromosome 21q21.3, is a zinc-dependent secreted metalloproteinase composed of an N-terminal propeptide, a metalloproteinase catalytic domain, a disintegrin-like module, a cysteine-rich region, a spacer and two C-terminal thrombospondin type-1 repeats; it functions as the principal aggrecanase that cleaves the cartilage proteoglycans aggrecan, versican, brevican and neurocan at Glu-Xaa motifs, thereby driving extracellular-matrix turnover during development, skeletal morphogenesis, adipose-tissue remodeling and T-lymphocyte trafficking, while its dysregulated activity contributes to osteoarthritis and inflammatory joint destruction, yet, intriguingly, the same protein—via its thrombospondin repeat 1—exerts anti-angiogenic and anti-tumorigenic effects independently of catalysis by suppressing VEGF, PlGF and PD-ECGF in the tumor milieu.

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SKU: 60469707950

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4.7 ★★★★★
Based on 83 reviews
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Product Reviews
C
Verified Purchase
Connie H. Lim
Battle Creek, US
★★★★★ 5
So lightweight, so smooth
I was looking for a retinol eye cream and decided to try this since I liked this brand before. The texture is super lightweight and absorbs well, and my makeup doesn’t pill at all after using it. Not sure yet about long-term wrinkle results, but it keeps my under-eye really hydrated and smooth. I’ve also been using it on my smile lines. lowkey excited to see more results!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 31, 2026
A
Amazon Customer
Phoenix, US
★★★★★ 3
Helped a bit with barrier, but it must be used very sparingly, and didn't improve fine lines for me.
I had mixed feelings about this eye cream. On paper, the combination of ingredients such as retinol, niacinamide, and centella sounded promising, especially for targeting texture and supporting the skin barrier. However, in practice, I found the formula to be a bit too strong for my sensitive eye area. I had to be very careful not to apply it too close to my eyes to avoid irritation. The cream is very thin and lightweight, and I found that it did absorb well without leaving too much of a greasy residue once applied. After about two weeks of consistent use, I did notice some positive changes. The skin under my eyes felt slightly more elastic, and my skin barrier seemed to be benefiting overall, which I appreciated. That said, I didn’t see any real improvement in fine lines or firmness, which is one of the main reasons I reach for an eye cream with retinol in the first place. The price point is definitely affordable, but it also feels like a case of getting what you pay for. While it’s not a bad product, it didn’t stand out enough for me to consider replacing my regular eye cream. At the end of the day, skincare is a long game. What we do now often shows up years down the line, so I do think it’s worth investing in higher-quality formulas when possible. For me, this one was just okay: some mild benefits, but ultimately unremarkable.
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Reviewed in the United States on May 3, 2026
J
Verified Purchase
Jennifer Donnelly
New York, US
★★★★★ 5
Pleasantly surprised
I’m two jars in and love it. I do use Botox, retinol, a good face wash, wash moisturize twice daily, etc etc. I struggle with moisturizer because I’m prone to breakouts. Idk what it is about this one but my skin loves it. It feels refreshed and soft. Added bonus, my eyebrows and lashes have gotten longer and darker quick! Obviously we all respond differently to products but I’ll be keeping this in my rotation
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Reviewed in the United States on June 3, 2026
D
Verified Purchase
Deb from the Ridge
Draper, US
★★★★★ 5
A thick and rich cream that smooths on nicely!
So I jumped on the Korean skincare bandwagon and decided to purchase some of the DR MELAXIN Products to try! I read many good reviews and decided it was worth the money. This first product is the Dr Melaxin Calcium cemenrete calcium volume cream. It comes in a 1.76 ounce glass jar. On the label there is a lot of word descriptions so I will add a few: Ex volume firming, rebornic 10,000 ppm hydrolyzed elastin and collagen extract. I have photographed label for viewing. The directions indicate to "apply a small amount of cream onto your face especially around the under-eye area". I found the cream thick and rich and I used it in addition to another Dr Melaxin neck and face product so I concentrated on only neck and under eye area. It is neutral in scent and is very thick so it feels like it is absorbing nicely. I have been using it for about a month now and have definitely noticed some improvement in the neck area so i will continue to use and layer with other products. I do recommend this line as the ingredients seem effective so far!
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Reviewed in the United States on June 4, 2026
E
Verified Purchase
E.R.
Omaha, US
★★★★★ 5
Good product for face.
Great product. Works well with decreasing lines in face after half is used and with the serum. It does leave somewhat of a sticky (not grimy) texture which is uncomfortable if using at night.
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Reviewed in the United States on June 1, 2026

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