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Description
APC Mouse Anti-Human CD206 Antibody (S-R575)Product Specification Host Mouse Antigen CD206 Synonyms Macrophage mannose receptor 1; MMR; C type lectin domain family 13 member D; C type lectin domain family 13 member D like; Human mannose receptor (hMR); Macrophage mannose receptor 1 like protein 1; CLEC13D; CLEC13DL; MRC1L1; MRC1 Location Endosome, Cell membrane Accession P22897 Clone Number S R575 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample GM CSF and IL
Product Specification
| Host | Mouse |
| Antigen | CD206 |
| Synonyms | Macrophage mannose receptor 1; MMR; C-type lectin domain family 13 member D; C-type lectin domain family 13 member D-like; Human mannose receptor (hMR); Macrophage mannose receptor 1-like protein 1; CLEC13D; CLEC13DL; MRC1L1; MRC1 |
| Location | Endosome, Cell membrane |
| Accession | P22897 |
| Clone Number | S-R575 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | GM-CSF and IL-4 treated human peripheral blood leukocytes |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | APC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD206, also known as the mannose receptor (MRC1), is a highly glycosylated type I transmembrane protein primarily expressed on the surface of macrophages and dendritic cells. It plays a crucial role in the innate immune response by mediating the endocytosis and phagocytosis of various pathogens, including bacteria, fungi, and viruses, through its ability to bind to mannan-coated cell walls or envelopes. CD206 is a marker for alternatively activated M2 macrophages, which are characterized by their anti-inflammatory phenotype and are involved in wound healing and immune tolerance. In the context of cancer, tumor-associated macrophages often exhibit high levels of CD206, contributing to tumor progression by promoting immunosuppression, metastasis, and angiogenesis. This makes CD206 a potential target for cancer immunotherapy, as its activation can enhance both adaptive and innate antitumor immune responses.
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