SKU: 61075206532

EGFR Fc Chimera Protein, Rhesus macaque

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Description

EGFR Fc Chimera Protein, Rhesus macaqueProduct Specification Species Rhesus macaque Synonyms ERBB,ERRP,HER1,mENA,ERBB1 Accession P55245 Amino Acid Sequence Leu25 Ser645, with C terminal Human IgG1 Fc

Product Specification


Species Rhesus macaque
Synonyms ERBB,ERRP,HER1,mENA,ERBB1
Accession P55245
Amino Acid Sequence

Leu25-Ser645, with C-terminal Human IgG1 Fc

LEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSEFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDTLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSSQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCQNVSRGRECVDKCNVLEGEPREFVENSECIQCHPECLPQVMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCARNGPKIPSIEGRMDPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK

Expression System HEK293
Molecular Weight 115-125kDa (Reducing)
Purity

>95% by SDS-PAGE

Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag Human Fc Tag
Physical Appearance Lyophilized Powder
Storage Buffer PBS, pH7.4
Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.

Background

The Epidermal Growth Factor Receptor (EGFR)is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).

 EGFR is activated after homodimerization or heterodimerization. Heterodimerization is an important mechanism that allows the activation of all EGFR in response to ligand stimulation. The activated EGFR binds to many signaling proteins and stimulates the activation of many signaling pathways. The specificity and potency of intracellular signaling pathways are determined by positive and negative regulators, the specific composition of activating ligand(s), receptor dimer components, and the diverse range of proteins that associate with the tyrosine phosphorylated C-terminal domain of the EGFR.EGFR is overexpressed or mutated in many cancers, especially in breast cancer, ovarian cancer, and non-small cell lung cancer. The overexpression and overactivation of EGFR is correlated with poor prognosis, drug resistance, cancer metastasis, and lower survival rate.

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Exchange/Return Notes
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SKU: 61075206532

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Amazon Customer
Boise, US
★★★★★ 5
Great value
Color: Navy Blue, Size: Medium
I love this shirt. Great value, great fit. Hidden button collar is a must.
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Reviewed in the United States on May 9, 2026
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Kenny Garon
Grantham, US
★★★★★ 1
Not what was expected
Color: Black, Size: X-Large
The shirt did not match the image on the website. While it is a button-down collar, the buttons are concealed, rather than exposed, and the material is polyester or nylon, giving the shirt a plastic sheen, which I do not like. The image on the website showed exposed buttons, and with tremors in my hands, exposed buttons are hard enough to secure.
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Reviewed in the United States on April 16, 2026
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Gonzalez Family
Fort Morgan, US
★★★★★ 5
Tela buena calidad
Good
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Reviewed in the United States on April 22, 2026
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Gary A Hill
West Palm Beach, US
★★★★★ 4
Sizeneed 3x
Color: White, Size: XX-Large
I’m to big so it’s to small need 3x
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Reviewed in the United States on February 12, 2026
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Michel Faulkner
Lowell, US
★★★★★ 5
Better that expected
Love the fit and fabric. Much better that I expected. I will be ordering more.
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Reviewed in the United States on April 4, 2026

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