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Description
CA2 Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen CA2 Synonyms Carbonic anhydrase 2; Carbonate dehydratase II; Carbonic anhydrase C (CAC); Carbonic anhydrase II (CA II); Cyanamide hydratase CA2 Immunogen Synthetic Peptide Location Cytoplasm, Cell membrane Accession P00918 Antibody Type Polyclonal antibody Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt Positive Sample Caco 2, MCF7, A431, HEK 293, mouse brain, rat brain Purification Immunogen
Product Specification
| Host | Rabbit |
| Antigen | CA2 |
| Synonyms | Carbonic anhydrase 2; Carbonate dehydratase II; Carbonic anhydrase C (CAC); Carbonic anhydrase II (CA-II); Cyanamide hydratase CA2 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Cell membrane |
| Accession | P00918 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | Caco-2, MCF7, A431, HEK-293, mouse brain, rat brain |
| Purification | Immunogen Affinity |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| IHC-P | 1:1000 | Hu, Ms, Rt |
| ICC | 1:500 | Hu |
Background
Carbonic anhydrase 2 (CA2) is a zinc-containing metalloenzyme that belongs to the carbonic anhydrase family and plays a crucial role in catalyzing the reversible hydration of carbon dioxide (CO₂) to bicarbonate (HCO₃⁻) and protons (H⁺). This reaction is essential for maintaining pH homeostasis, electrolyte balance, and CO₂ transport in various tissues, including the kidneys, red blood cells, and the central nervous system. CA2 is one of the most efficient enzymes, with a catalytic rate approaching diffusion limits, and its activity is critical for physiological processes such as respiration, bone resorption, renal acid secretion, and cerebrospinal fluid production. Mutations in the CA2 gene can lead to osteopetrosis with renal tubular acidosis and cerebral calcification, highlighting its importance in bone remodeling and acid-base regulation. Additionally, CA2 is implicated in pathological conditions, including cancer, glaucoma, and epilepsy, making it a potential therapeutic target for inhibitors like acetazolamide. Its structure consists of a conserved α-carbonic anhydrase fold with a zinc ion coordinated by three histidine residues in the active site, enabling rapid proton transfer via a water-mediated mechanism.
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