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Description
NGFR/TNFRSF16 Fc Chimera Protein, HumanProduct Specification Species Human Synonyms Gp80 LNGFRNGF ReceptorLow Affinity Neurotrophin Receptor P75NTRNerve Growth Factor Receptor (TNFR Superfamily Member 16)NGFRTNFR Superfamily Member 16Tumor Necrosis Factor Receptor Superfamily Member 16CD271CD271 AntigenLow Affinity Nerve Growth Factor ReceptorLow Affinity Nerve Growth Factor ReceptorP75 ICDNerve Growth Factor ReceptorP75(NTR)TNFRSF16P75NTR Accession P08138 1 Amino Acid Sequence Lys29
Product Specification
| Species | Human |
| Synonyms | Gp80-LNGFR，NGF Receptor，Low Affinity Neurotrophin Receptor P75NTR，Nerve Growth Factor Receptor (TNFR Superfamily， Member 16)，NGFR，TNFR Superfamily， Member 16，Tumor Necrosis Factor Receptor Superfamily Member 16，CD271，CD271 Antigen，Low Affinity Nerve Growth Factor Receptor，Low-Affinity Nerve Growth Factor Receptor，P75 ICD，Nerve Growth Factor Receptor，P75(NTR)，TNFRSF16，P75NTR |
| Accession | P08138-1 |
| Amino Acid Sequence | Lys29-Asn250, with C-hIgG Fc |
| Expression System | HEK293 |
| Molecular Weight | 70-90kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE & >90% by RP-HPLC |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Barker, P.A. and R.A. Murphy (1992) Molecular and Cellular Biochemistry 110:1. |
Background
p75 neurotrophin receptor, also named low affinity NGF receptor (NGF R), is a type I transmembrane protein that belongs to the tumor necrosis factor receptor family. The extracellular region contains four cysteine-rich domains and binds NGF, BDNF, NT-3 and NT-4 approximately equally with low affinity. The cytoplasmic region contains a subtype 2 death domain. NGF R expression has been shown to occur widely during development and in the adult. Expression has been detected in both neuronal and non-neuronal cells. NGF R was originally reported to function as a positive regulator of TrkA activity. NGF R has also been shown to signal by itself. Depending on its cellular environment, NGF R has now been shown to regulate cell migration, gene expression and to mediate apoptosis. Recombinant NGF R/Fc chimera binds NGF with high affinity and is a potent NGF antagonist. Naturally occurring truncated NGF R containing the extracellular domain and lacking the transmembrane or intracellular domain has been detected in vivo in urine, plasma and in amniotic fluid of humans and rats.
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