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Description
APC Rabbit Anti-Human Glypican-3 Antibody (SDT-R032)Product Specification Host Rabbit Antigen Glypican 3 Synonyms GTR2 2; Intestinal protein OCI 5; MXR7; OCI5; GPC3 Location Cell membrane Accession P51654 Clone Number SDT R032 Antibody Type Recombinant mAb Isotype IgG Application FCM Reactivity Hu Positive Sample HepG2 Purification Protein A Concentration 0. 05mg ml Conjugation APC Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0. 3% Proclin 300 Stability & Storage 12 months from date of
Product Specification
| Host | Rabbit |
| Antigen | Glypican-3 |
| Synonyms | GTR2-2; Intestinal protein OCI-5; MXR7; OCI5; GPC3 |
| Location | Cell membrane |
| Accession | P51654 |
| Clone Number | SDT-R032 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | HepG2 |
| Purification | Protein A |
| Concentration | 0.05mg/ml |
| Conjugation | APC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
Glypican-3 (GPC3) is a cell-surface glycoprotein that is highly expressed in hepatocellular carcinoma (HCC) and some other cancers. It is a member of the glypican family of heparan sulfate proteoglycans, consisting of a core protein and heparan sulfate chains, and is anchored to the cell membrane via a glycosylphosphatidylinositol (GPI) anchor. GPC3 is encoded by the GPC3 gene located on the X chromosome and is cleaved by furin into an N-terminal 40 kDa subunit and a C-terminal 30 kDa subunit. It plays a role in cell proliferation, morphogenesis, and oncogenesis by interacting with signaling pathways such as Wnt, Hedgehog, and fibroblast growth factor. Abnormal expression of GPC3 is associated with poor prognosis in cancer, making it a potential target for cancer diagnosis and immunotherapy.
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