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Description
FITC Rat Anti-Mouse CD122 (IL-2Rβ) Antibody (S-4060)Product Specification Host Rat Antigen CD122 (IL 2R) Synonyms Interleukin 2 receptor subunit beta; IL 2 receptor subunit beta; IL 2R subunit beta; IL 2RB; High affinity IL 2 receptor subunit beta; p70 75; Il2rb Location Cell membrane Accession P16297 Clone Number S 4060 Antibody Type Rat mAb Isotype IgG2b,k Application FCM Reactivity Ms Positive Sample C57BL 6 mouse splenocytes Purification Protein G Concentration 0. 2 mg ml Conjugation FITC Physical
Product Specification
| Host | Rat |
| Antigen | CD122 (IL-2Rβ) |
| Synonyms | Interleukin-2 receptor subunit beta; IL-2 receptor subunit beta; IL-2R subunit beta; IL-2RB; High affinity IL-2 receptor subunit beta; p70-75; Il2rb |
| Location | Cell membrane |
| Accession | P16297 |
| Clone Number | S-4060 |
| Antibody Type | Rat mAb |
| Isotype | IgG2b,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse splenocytes |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | FITC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Ms |
Background
CD122, also known as interleukin-2 receptor beta (IL-2Rβ), is a 75 kDa type I transmembrane glycoprotein that serves as the shared signaling subunit for the IL-2, IL-7 and IL-15 cytokine receptors; upon ligand binding it heterodimerizes with IL-2Rγc to activate JAK1/JAK3–STAT5, PI3K–AKT and MAPK pathways that drive survival, proliferation and cytolytic programs in T, B, NK and memory T cells, making it a central regulator of both lymphocyte homeostasis and potent target for immunotherapies against cancer and autoimmunity.
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