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Description
MyoD1 Recombinant Rabbit mAb (S-2519-63)Product Specification Host Rabbit Antigen MyoD1 Synonyms Myoblast determination protein 1; Class C basic helix loop helix protein 1 (bHLHc1); Myogenic factor 3 (Myf 3); BHLHC1; MYF3; MYOD; MYOD1 Immunogen Synthetic Peptide Location Nucleus Accession P15172 Clone Number S 2519 63 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu Positive Sample RD Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical
Product Specification
| Host | Rabbit |
| Antigen | MyoD1 |
| Synonyms | Myoblast determination protein 1; Class C basic helix-loop-helix protein 1 (bHLHc1); Myogenic factor 3 (Myf-3); BHLHC1; MYF3; MYOD; MYOD1 |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | P15172 |
| Clone Number | S-2519-63 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu |
| Positive Sample | RD |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:500-1:1000 | Hu |
Background
MyoD1 (Myogenic Differentiation 1) is a basic helix-loop-helix (bHLH) transcription factor that serves as a master regulator of skeletal muscle differentiation, initiating the myogenic program by binding to E-box DNA sequences and activating the transcription of muscle-specific genes such as myogenin, MEF2, and muscle creatine kinase (MCK). Discovered in 1987, MyoD1 belongs to the MyoD family of myogenic regulatory factors (MRFs), which also includes Myf5, myogenin, and MRF4, and it can convert non-muscle cells, including fibroblasts, adipocytes, and even hepatocytes, into myoblasts through forced expression. The protein functions as a heterodimer with E-proteins (such as E12 and E47) to regulate cell cycle withdrawal and terminal differentiation, while its activity is modulated by various signaling pathways including p38 MAPK, PI3K/Akt, and Wnt signaling, as well as post-translational modifications like phosphorylation, acetylation, and ubiquitination. Beyond its canonical role in myogenesis, MyoD1 has been implicated in cancer biology, particularly in rhabdomyosarcoma where it serves as a diagnostic marker, and in metabolic regulation, highlighting its broad physiological significance.
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