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Description
Mouse Anti-Human CD185 Antibody (S-R653)Product Specification Host Mouse Antigen CD185 Synonyms C X C chemokine receptor type 5; CXC R5; CXCR 5; Burkitt lymphoma receptor 1; Monocyte derived receptor 15 (MDR 15); CXCR5; BLR1; MDR15 Location Cell membrane Accession P32302 Clone Number S R653 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample human PBMC Purification Protein G Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage
Product Specification
| Host | Mouse |
| Antigen | CD185 |
| Synonyms | C-X-C chemokine receptor type 5; CXC-R5; CXCR-5; Burkitt lymphoma receptor 1; Monocyte-derived receptor 15 (MDR-15); CXCR5; BLR1; MDR15 |
| Location | Cell membrane |
| Accession | P32302 |
| Clone Number | S-R653 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | human PBMC |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 1:2000 | Hu |
Background
CD185, also known as CXCR5 or Burkitt lymphoma receptor 1 (BLR1), is a G protein-coupled seven-transmembrane receptor that belongs to the CXC chemokine receptor family. It is specifically expressed in Burkitt's lymphoma and lymphatic tissues, such as follicles in lymph nodes and the spleen, and plays a crucial role in B cell migration and the development of lymph nodes and Peyer's patches. CXCR5 enables T cells to migrate to lymph node and B cell zones, which is essential for the production of high-affinity antibodies as B cells and T cells need to interact to activate the Ig class switch. This receptor is expressed on both CD4 and CD8 T cells and is often regarded as a defining marker for T Follicular Helper (Tfh) cells.
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Exchange/Return Notes
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